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Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6813-8. doi: 10.1073/pnas.0800712105. Epub 2008 May 7.
Proc Natl Acad Sci U S A. 2008.
PMID: 18463291
Free PMC article.
Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.
Smith DP, Ciccotosto GD, Tew DJ, Fodero-Tavoletti MT, Johanssen T, Masters CL, Barnham KJ, Cappai R.
Smith DP, et al.
Biochemistry. 2007 Mar 13;46(10):2881-91. doi: 10.1021/bi0620961. Epub 2007 Feb 13.
Biochemistry. 2007.
PMID: 17297919
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Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R.
Ciccotosto GD, et al.
Neurobiol Aging. 2011 Feb;32(2):235-48. doi: 10.1016/j.neurobiolaging.2009.02.018. Epub 2009 Mar 25.
Neurobiol Aging. 2011.
PMID: 19324459
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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI.
Duce JA, et al.
Cell. 2010 Sep 17;142(6):857-67. doi: 10.1016/j.cell.2010.08.014.
Cell. 2010.
PMID: 20817278
Free PMC article.
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Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.
Watt AD, Perez KA, Rembach A, Sherrat NA, Hung LW, Johanssen T, McLean CA, Kok WM, Hutton CA, Fodero-Tavoletti M, Masters CL, Villemagne VL, Barnham KJ.
Watt AD, et al.
Acta Neuropathol. 2013 Apr;125(4):549-64. doi: 10.1007/s00401-013-1083-z. Epub 2013 Jan 25.
Acta Neuropathol. 2013.
PMID: 23354835
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Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.
Gunn AP, Wong BX, Johanssen T, Griffith JC, Masters CL, Bush AI, Barnham KJ, Duce JA, Cherny RA.
Gunn AP, et al.
J Biol Chem. 2016 Mar 18;291(12):6134-45. doi: 10.1074/jbc.M115.655183. Epub 2015 Dec 23.
J Biol Chem. 2016.
PMID: 26697885
Free PMC article.
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C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage.
Johanssen VA, Johanssen T, Masters CL, Hill AF, Barnham KJ, Collins SJ.
Johanssen VA, et al.
Biochem J. 2014 Apr 1;459(1):103-15. doi: 10.1042/BJ20131378.
Biochem J. 2014.
PMID: 24438129
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PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.
Johanssen T, Suphantarida N, Donnelly PS, Liu XM, Petrou S, Hill AF, Barnham KJ.
Johanssen T, et al.
Neurobiol Dis. 2015 Sep;81:176-85. doi: 10.1016/j.nbd.2015.02.008. Epub 2015 Feb 17.
Neurobiol Dis. 2015.
PMID: 25697105
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