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Year Number of Results
2016 1
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2019 3
2020 2
2021 2
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2023 3
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19 results

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Page 1
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia.
Kim-Muller JY, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, Joaquim S, Stansfield JC, Zhang J, Robertson A, Pang J, Opsahl A, Boucher M, Breen D, Hales K, Sheikh A, Wu Z, Zhang BB. Kim-Muller JY, et al. Among authors: stansfield jc. Cell Rep. 2023 Jan 31;42(1):111947. doi: 10.1016/j.celrep.2022.111947. Epub 2023 Jan 10. Cell Rep. 2023. PMID: 36640326 Free article.
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.
Filipski KJ, Martinez-Alsina LA, Reese MR, Evrard E, Buzon LM, Cameron KO, Zhang Y, Coffman KJ, Bradow J, Kormos BL, Liu S, Knafels JD, Sahasrabudhe PV, Chen J, Kalgutkar AS, Bessire AJ, Orozco CC, Balesano A, Cerny MA, Bollinger E, Reyes AR, Laforest B, Rosado A, Williams G, Marshall M, Tam Neale K, Chen X, Hirenallur-Shanthappa D, Stansfield JC, Groarke J, Qiu R, Karas S, Roth Flach RJ, Esler WP. Filipski KJ, et al. Among authors: stansfield jc. J Med Chem. 2025 Feb 13;68(3):2466-2482. doi: 10.1021/acs.jmedchem.4c02230. Epub 2024 Nov 19. J Med Chem. 2025. PMID: 39560668
Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models.
Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X, Marshall M, Jagarlapudi S, Jami-Alahmadi Y, Jean-Beltran PM, Song L, Chiou J, Geoly F, Vargas SR, Zhang Y, Kuang E, Callahan D, Stansfield JC, Russo M, Griffin J, Sun Z, Miller MR, Hyde CL, Clasquin MF, Hales K, Daurio NA, Crane JD, Hirenallur-Shanthappa D, Groarke J, Zhang BB, Roth Flach RJ. Bollinger E, et al. Among authors: stansfield jc. Kidney Int. 2025 Aug;108(2):310-316. doi: 10.1016/j.kint.2025.04.025. Epub 2025 May 21. Kidney Int. 2025. PMID: 40409667 Free article.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Among authors: stansfield jc. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Roth Flach RJ, Bollinger E, Reyes AR, Laforest B, Kormos BL, Liu S, Reese MR, Martinez Alsina LA, Buzon L, Zhang Y, Bechle B, Rosado A, Sahasrabudhe PV, Knafels J, Bhattacharya SK, Omoto K, Stansfield JC, Hurley LD, Song L, Luo L, Breitkopf SB, Monetti M, Cunio T, Tierney B, Geoly FJ, Delmore J, Siddall CP, Xue L, Yip KN, Kalgutkar AS, Miller RA, Zhang BB, Filipski KJ. Roth Flach RJ, et al. Among authors: stansfield jc. Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y. Nat Commun. 2023. PMID: 37558654 Free PMC article.
An assessment of thermoneutral housing conditions on murine cardiometabolic function.
Chen X, Bollinger E, Cunio T, Damilano F, Stansfield JC, Pinkus CA, Kreuser S, Hirenallur-Shanthappa D, Roth Flach RJ. Chen X, et al. Among authors: stansfield jc. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H234-H245. doi: 10.1152/ajpheart.00461.2021. Epub 2021 Dec 17. Am J Physiol Heart Circ Physiol. 2022. PMID: 34919456 Free article.
19 results