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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2002 5
2003 7
2004 6
2005 12
2006 13
2007 15
2008 4
2009 7
2010 12
2011 19
2012 14
2013 8
2014 13
2015 7
2016 10
2017 4
2018 9
2019 18
2020 5
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180 results
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Page 1
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Liu S, et al. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. Cell. 2019. PMID: 30612740 Free PMC article.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA Jr, Pelletier J, Rätsch G, Wendel HG. Wolfe AL, et al. Among authors: porco ja jr. Nature. 2014 Sep 4;513(7516):65-70. doi: 10.1038/nature13485. Epub 2014 Jul 27. Nature. 2014. PMID: 25079319 Free PMC article.
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC. Chan K, et al. Among authors: porco ja jr. Nat Commun. 2019 Nov 13;10(1):5151. doi: 10.1038/s41467-019-13086-5. Nat Commun. 2019. PMID: 31723131 Free PMC article.
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.
Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA Jr, Pelletier J. Chu J, et al. Among authors: porco ja jr. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593.e3. doi: 10.1016/j.chembiol.2019.08.008. Epub 2019 Sep 10. Cell Chem Biol. 2019. PMID: 31519508
eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer.
Kong T, Xue Y, Cencic R, Zhu X, Monast A, Fu Z, Pilon V, Sangwan V, Guiot MC, Foulkes WD, Porco JA Jr, Park M, Pelletier J, Huang S. Kong T, et al. Among authors: porco ja jr. Mol Cancer Ther. 2019 Nov;18(11):2158-2170. doi: 10.1158/1535-7163.MCT-19-0162. Epub 2019 Aug 8. Mol Cancer Ther. 2019. PMID: 31395685
Tracing MYC Expression for Small Molecule Discovery.
Steinberger J, Robert F, Hallé M, Williams DE, Cencic R, Sawhney N, Pelletier D, Williams P, Igarashi Y, Porco JA Jr, Rodriguez AD, Kopp B, Bachmann B, Andersen RJ, Pelletier J. Steinberger J, et al. Among authors: porco ja jr. Cell Chem Biol. 2019 May 16;26(5):699-710.e6. doi: 10.1016/j.chembiol.2019.02.007. Epub 2019 Mar 14. Cell Chem Biol. 2019. PMID: 30880156 Free PMC article.
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Kearney SE, et al. Among authors: porco ja jr. ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5. ACS Cent Sci. 2018. PMID: 30648156 Free PMC article.
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas.
Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA Jr, Fu K. Zhang X, et al. Among authors: porco ja jr. Leukemia. 2020 Jan;34(1):138-150. doi: 10.1038/s41375-019-0503-z. Epub 2019 Jun 6. Leukemia. 2020. PMID: 31171817 Free PMC article.
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Among authors: porco ja jr. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.
Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.
Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM. Manier S, et al. Among authors: porco ja jr. Sci Transl Med. 2017 May 10;9(389):eaal2668. doi: 10.1126/scitranslmed.aal2668. Sci Transl Med. 2017. PMID: 28490664 Free PMC article.
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