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Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.
Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG. Roddy TP, et al. Among authors: johns dg. Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21. Eur J Pharmacol. 2014. PMID: 24769414
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
Ni YG, Di Marco S, Condra JH, Peterson LB, Wang W, Wang F, Pandit S, Hammond HA, Rosa R, Cummings RT, Wood DD, Liu X, Bottomley MJ, Shen X, Cubbon RM, Wang SP, Johns DG, Volpari C, Hamuro L, Chin J, Huang L, Zhao JZ, Vitelli S, Haytko P, Wisniewski D, Mitnaul LJ, Sparrow CP, Hubbard B, Carfí A, Sitlani A. Ni YG, et al. Among authors: johns dg. J Lipid Res. 2011 Jan;52(1):78-86. doi: 10.1194/jlr.M011445. Epub 2010 Oct 19. J Lipid Res. 2011. PMID: 20959675 Free PMC article.
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.
McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, Balkovec JM, DeVita RJ, Marsh DJ, Castro-Perez JM, Strack A, Johns DG, Previs SF, Hubbard BK, Roddy TP. McLaren DG, et al. Among authors: johns dg. J Lipid Res. 2011 Jun;52(6):1150-1161. doi: 10.1194/jlr.M011049. Epub 2011 Mar 17. J Lipid Res. 2011. PMID: 21415123 Free PMC article.
Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics.
Castro-Perez JM, Roddy TP, Shah V, McLaren DG, Wang SP, Jensen K, Vreeken RJ, Hankemeier T, Johns DG, Previs SF, Hubbard BK. Castro-Perez JM, et al. Among authors: johns dg. J Proteome Res. 2011 Sep 2;10(9):4281-90. doi: 10.1021/pr200480g. Epub 2011 Aug 4. J Proteome Res. 2011. PMID: 21744776
Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L. Castro-Perez JM, et al. Among authors: johns dg. J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26. J Proteome Res. 2011. PMID: 21819150
246 results