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Necroptosis: MLKL Polymerization.
Johnston A, Wang Z. Johnston A, et al. J Nat Sci. 2018 Jul;4(7):e513. J Nat Sci. 2018. PMID: 30294675 Free PMC article.
Necroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers caspase independent, immunogenic cell death. ...MLKL polymerizes to form a
Necroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death re …
MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.
Liu S, Liu H, Johnston A, Hanna-Addams S, Reynoso E, Xiang Y, Wang Z. Liu S, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7450-E7459. doi: 10.1073/pnas.1707531114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827318 Free PMC article.
Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.
Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z. Johnston AN, et al. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6521-6530. doi: 10.1073/pnas.1916503117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156734 Free PMC article.
Interestingly, knockdown of Hsp70 in cells leads to MLKL destabilization, suggesting that MLKL might also be a client protein of Hsp70. In summary, using NBC1, an inhibitor of necroptosis, we identified Hsp70 as a molecular chaperone performing dual functions in nec …
Interestingly, knockdown of Hsp70 in cells leads to MLKL destabilization, suggesting that MLKL might also be a client protein of Hsp7 …
HSP70 promotes MLKL polymerization and necroptosis.
Johnston AN, Wang Z. Johnston AN, et al. Mol Cell Oncol. 2020 Jul 14;7(5):1791561. doi: 10.1080/23723556.2020.1791561. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32944645
Laboratory practices for manual blood film review: Results of an IQMH patterns of practice survey.
Leung E, Johnston A, Olsen B, Chang H, Martin T, Wozniak M, Good D. Leung E, et al. Among authors: johnston a. Int J Lab Hematol. 2020 Sep 17. doi: 10.1111/ijlh.13343. Online ahead of print. Int J Lab Hematol. 2020. PMID: 32940011
Longitudinal description and evaluation of an emergency department avoidance strategy for a youth mass gathering (Schoolies) in Australia.
Johnston AN, Byrne JH, Bost N, Aitken M, Wadham J, Donnelly T, Timms J, Crilly J. Johnston AN, et al. Emerg Med Australas. 2020 Sep 15. doi: 10.1111/1742-6723.13609. Online ahead of print. Emerg Med Australas. 2020. PMID: 32929847
Fatigue and recovery in shiftworking nurses: A scoping literature review.
Gifkins J, Johnston A, Loudoun R, Troth A. Gifkins J, et al. Among authors: johnston a. Int J Nurs Stud. 2020 Jul 11:103710. doi: 10.1016/j.ijnurstu.2020.103710. Online ahead of print. Int J Nurs Stud. 2020. PMID: 32912638
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells.
FitzGerald LI, Aurelio L, Chen M, Yuen D, Rennick JJ, Graham B, Johnston APR. FitzGerald LI, et al. Among authors: johnston apr. Nat Commun. 2020 Sep 8;11(1):4482. doi: 10.1038/s41467-020-18082-8. Nat Commun. 2020. PMID: 32901011
Repeated Application of a Novel Creatine Cream Improves Muscular Peak and Average Power in Male Subjects.
Whinton AK, Donahoe K, Gao R, Thompson KMA, Aubry R, Saunders TJ, Johnston A, Chilibeck PD, Burr JF. Whinton AK, et al. Among authors: johnston a. J Strength Cond Res. 2020 Sep;34(9):2482-2491. doi: 10.1519/JSC.0000000000003730. J Strength Cond Res. 2020. PMID: 32865944
Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer.
Hall PE, Ready N, Johnston A, Bomalaski JS, Venhaus RR, Sheaff M, Krug L, Szlosarek PW. Hall PE, et al. Among authors: johnston a. Clin Lung Cancer. 2020 Jul 30:S1525-7304(20)30234-5. doi: 10.1016/j.cllc.2020.07.012. Online ahead of print. Clin Lung Cancer. 2020. PMID: 32859536
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