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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Ruefli AA, et al. Among authors: johnstone rw. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8. doi: 10.1073/pnas.191208598. Epub 2001 Sep 4. Proc Natl Acad Sci U S A. 2001. PMID: 11535817 Free PMC article.
Mechanisms of interferon mediated anti-viral resistance.
Clarke CJ, Trapani JA, Johnstone RW. Clarke CJ, et al. Among authors: johnstone rw. Curr Drug Targets Immune Endocr Metabol Disord. 2001 Aug;1(2):117-30. Curr Drug Targets Immune Endocr Metabol Disord. 2001. PMID: 12476793 Review.
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