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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.
Johnstone RW. Johnstone RW. Nat Rev Drug Discov. 2002 Apr;1(4):287-99. doi: 10.1038/nrd772. Nat Rev Drug Discov. 2002. PMID: 12120280 Review.
Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival.
Johnstone RW, Gerber M, Landewe T, Tollefson A, Wold WS, Shilatifard A. Johnstone RW, et al. Mol Cell Biol. 2001 Mar;21(5):1672-81. doi: 10.1128/MCB.21.5.1672-1681.2001. Mol Cell Biol. 2001. PMID: 11238904 Free PMC article.
P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
Johnstone RW, Tainton KM, Ruefli AA, Froelich CJ, Cerruti L, Jane SM, Smyth MJ. Johnstone RW, et al. J Biol Chem. 2001 May 18;276(20):16667-73. doi: 10.1074/jbc.M010774200. Epub 2001 Feb 20. J Biol Chem. 2001. PMID: 11278745
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Ruefli AA, et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8. doi: 10.1073/pnas.191208598. Epub 2001 Sep 4. Proc Natl Acad Sci U S A. 2001. PMID: 11535817 Free PMC article.
Apoptosis: a link between cancer genetics and chemotherapy.
Johnstone RW, Ruefli AA, Lowe SW. Johnstone RW, et al. Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6. Cell. 2002. PMID: 11832206 Review.
Deamidation of Bcl-X(L): a new twist in a genotoxic murder mystery.
Johnstone RW. Johnstone RW. Mol Cell. 2002 Oct;10(4):695-7. doi: 10.1016/s1097-2765(02)00693-7. Mol Cell. 2002. PMID: 12419210
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