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Anticancer activities of histone deacetylase inhibitors.
Bolden JE, Peart MJ, Johnstone RW. Bolden JE, et al. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. doi: 10.1038/nrd2133. Nat Rev Drug Discov. 2006. PMID: 16955068 Review.
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.
Browne KA, Johnstone RW, Jans DA, Trapani JA. Browne KA, et al. J Biol Chem. 2000 Dec 15;275(50):39262-6. doi: 10.1074/jbc.C000622200. J Biol Chem. 2000. PMID: 11050075
Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival.
Johnstone RW, Gerber M, Landewe T, Tollefson A, Wold WS, Shilatifard A. Johnstone RW, et al. Mol Cell Biol. 2001 Mar;21(5):1672-81. doi: 10.1128/MCB.21.5.1672-1681.2001. Mol Cell Biol. 2001. PMID: 11238904 Free PMC article.
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Ruefli AA, et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8. doi: 10.1073/pnas.191208598. Epub 2001 Sep 4. Proc Natl Acad Sci U S A. 2001. PMID: 11535817 Free PMC article.
Apoptosis: a link between cancer genetics and chemotherapy.
Johnstone RW, Ruefli AA, Lowe SW. Johnstone RW, et al. Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6. Cell. 2002. PMID: 11832206 Review.
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.
Johnstone RW. Johnstone RW. Nat Rev Drug Discov. 2002 Apr;1(4):287-99. doi: 10.1038/nrd772. Nat Rev Drug Discov. 2002. PMID: 12120280 Review.
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