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The TRAIL apoptotic pathway in cancer onset, progression and therapy.
Johnstone RW, Frew AJ, Smyth MJ. Johnstone RW, et al. Nat Rev Cancer. 2008 Oct;8(10):782-98. doi: 10.1038/nrc2465. Nat Rev Cancer. 2008. PMID: 18813321 Review.
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.
Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA. Sutton VR, et al. J Exp Med. 2000 Nov 20;192(10):1403-14. doi: 10.1084/jem.192.10.1403. J Exp Med. 2000. PMID: 11085743 Free PMC article.
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Ruefli AA, et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8. doi: 10.1073/pnas.191208598. Epub 2001 Sep 4. Proc Natl Acad Sci U S A. 2001. PMID: 11535817 Free PMC article.
Apoptosis: a link between cancer genetics and chemotherapy.
Johnstone RW, Ruefli AA, Lowe SW. Johnstone RW, et al. Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6. Cell. 2002. PMID: 11832206 Review.
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.
Johnstone RW. Johnstone RW. Nat Rev Drug Discov. 2002 Apr;1(4):287-99. doi: 10.1038/nrd772. Nat Rev Drug Discov. 2002. PMID: 12120280 Review.
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