Jones CR - Search Results

1

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.

Hatley OJD, Jones CR, Galetin A, Rostami-Hodjegan A. Hatley OJD, et al. Among authors: jones cr. Biopharm Drug Dispos. 2017 Apr;38(3):187-208. doi: 10.1002/bdd.2070. Biopharm Drug Dispos. 2017. PMID: 28207929 Free PMC article.

2

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.

Jones CR, Hatley OJ, Ungell AL, Hilgendorf C, Peters SA, Rostami-Hodjegan A. Jones CR, et al. AAPS J. 2016 May;18(3):589-604. doi: 10.1208/s12248-016-9889-y. Epub 2016 Mar 10. AAPS J. 2016. PMID: 26964996 Free PMC article. Review.

3

Quantifying gut wall metabolism: methodology matters.

Hatley OJ, Jones CR, Galetin A, Rostami-Hodjegan A. Hatley OJ, et al. Among authors: jones cr. Biopharm Drug Dispos. 2017 Mar;38(2):155-160. doi: 10.1002/bdd.2062. Epub 2017 Feb 14. Biopharm Drug Dispos. 2017. PMID: 28039878 Free PMC article. No abstract available.

4

Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance.

Scotcher D, Billington S, Brown J, Jones CR, Brown CDA, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. Among authors: jones cr. Drug Metab Dispos. 2017 May;45(5):556-568. doi: 10.1124/dmd.117.075242. Epub 2017 Mar 7. Drug Metab Dispos. 2017. PMID: 28270564 Free PMC article.

5

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Scotcher D, Jones C, Posada M, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. AAPS J. 2016 Sep;18(5):1067-1081. doi: 10.1208/s12248-016-9942-x. Epub 2016 Jun 30. AAPS J. 2016. PMID: 27365096 Review.

6

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

Scotcher D, Jones C, Posada M, Galetin A, Rostami-Hodjegan A. Scotcher D, et al. AAPS J. 2016 Sep;18(5):1082-1094. doi: 10.1208/s12248-016-9959-1. Epub 2016 Aug 9. AAPS J. 2016. PMID: 27506526 Review.

7

Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models.

Peters SA, Jones CR, Ungell AL, Hatley OJ. Peters SA, et al. Among authors: jones cr. Clin Pharmacokinet. 2016 Jun;55(6):673-96. doi: 10.1007/s40262-015-0351-6. Clin Pharmacokinet. 2016. PMID: 26895020 Free PMC article. Review.

8

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.

Scotcher D, Jones CR, Galetin A, Rostami-Hodjegan A. Scotcher D, et al. Among authors: jones cr. J Pharmacol Exp Ther. 2017 Mar;360(3):484-495. doi: 10.1124/jpet.116.237438. Epub 2017 Jan 5. J Pharmacol Exp Ther. 2017. PMID: 28057840 Free PMC article.

9

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance.

Scotcher D, Jones C, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. Eur J Pharm Sci. 2016 Oct 30;94:59-71. doi: 10.1016/j.ejps.2016.03.018. Epub 2016 Mar 28. Eur J Pharm Sci. 2016. PMID: 27033147 Free PMC article.

10

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.

Sohlenius-Sternbeck AK, Jones C, Ferguson D, Middleton BJ, Projean D, Floby E, Bylund J, Afzelius L. Sohlenius-Sternbeck AK, et al. Xenobiotica. 2012 Sep;42(9):841-53. doi: 10.3109/00498254.2012.669080. Epub 2012 Apr 18. Xenobiotica. 2012. PMID: 22509824

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