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Regulation of p53 stability by Mdm2.
Kubbutat MH, Jones SN, Vousden KH. Kubbutat MH, et al. Among authors: jones sn. Nature. 1997 May 15;387(6630):299-303. doi: 10.1038/387299a0. Nature. 1997. PMID: 9153396
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Jones SN, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15608-12. doi: 10.1073/pnas.95.26.15608. Proc Natl Acad Sci U S A. 1998. PMID: 9861017 Free PMC article.
JNK targets p53 ubiquitination and degradation in nonstressed cells.
Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z. Fuchs SY, et al. Among authors: jones sn. Genes Dev. 1998 Sep 1;12(17):2658-63. doi: 10.1101/gad.12.17.2658. Genes Dev. 1998. PMID: 9732264 Free PMC article.
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells.
Wang P, Lushnikova T, Odvody J, Greiner TC, Jones SN, Eischen CM. Wang P, et al. Among authors: jones sn. Oncogene. 2008 Mar 6;27(11):1590-8. doi: 10.1038/sj.onc.1210788. Epub 2007 Sep 10. Oncogene. 2008. PMID: 17828300
An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
Steinman HA, Burstein E, Lengner C, Gosselin J, Pihan G, Duckett CS, Jones SN. Steinman HA, et al. Among authors: jones sn. J Biol Chem. 2004 Feb 6;279(6):4877-86. doi: 10.1074/jbc.M305966200. Epub 2003 Nov 10. J Biol Chem. 2004. PMID: 14612455
Phosphorylation of serine 18 regulates distinct p53 functions in mice.
Sluss HK, Armata H, Gallant J, Jones SN. Sluss HK, et al. Among authors: jones sn. Mol Cell Biol. 2004 Feb;24(3):976-84. doi: 10.1128/mcb.24.3.976-984.2004. Mol Cell Biol. 2004. PMID: 14729946 Free PMC article.
Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.
Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Lengner CJ, et al. Among authors: jones sn. J Cell Biol. 2006 Mar 13;172(6):909-21. doi: 10.1083/jcb.200508130. J Cell Biol. 2006. PMID: 16533949 Free PMC article.
Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice.
Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Shin J, et al. Among authors: jones sn. Nature. 2010 Oct 21;467(7318):977-81. doi: 10.1038/nature09457. Nature. 2010. PMID: 20962847 Free PMC article.
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.
Gannon HS, Donehower LA, Lyle S, Jones SN. Gannon HS, et al. Among authors: jones sn. Dev Biol. 2011 May 1;353(1):1-9. doi: 10.1016/j.ydbio.2011.02.007. Epub 2011 Feb 17. Dev Biol. 2011. PMID: 21334322 Free PMC article.
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. Lu X, et al. Among authors: jones sn. Cancer Cell. 2007 Oct;12(4):342-54. doi: 10.1016/j.ccr.2007.08.033. Cancer Cell. 2007. PMID: 17936559
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