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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O'Connor MJ, Martin NM, Borst P, Jonkers J. Rottenberg S, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. doi: 10.1073/pnas.0806092105. Epub 2008 Oct 29. Proc Natl Acad Sci U S A. 2008. PMID: 18971340 Free PMC article.
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells.
Loonstra A, Vooijs M, Beverloo HB, Allak BA, van Drunen E, Kanaar R, Berns A, Jonkers J. Loonstra A, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9209-14. doi: 10.1073/pnas.161269798. Proc Natl Acad Sci U S A. 2001. PMID: 11481484 Free PMC article.
Frat is dispensable for canonical Wnt signaling in mammals.
van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der Gulden H, Jonkers J, Berns A. van Amerongen R, et al. Among authors: jonkers j. Genes Dev. 2005 Feb 15;19(4):425-30. doi: 10.1101/gad.326705. Epub 2005 Jan 28. Genes Dev. 2005. PMID: 15681612 Free PMC article.
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.
Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J. Derksen PW, et al. Among authors: jonkers j. Cancer Cell. 2006 Nov;10(5):437-49. doi: 10.1016/j.ccr.2006.09.013. Cancer Cell. 2006. PMID: 17097565 Free article.
Further evidence for BRCA1 communication with the inactive X chromosome.
Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM. Silver DP, et al. Among authors: jonkers j. Cell. 2007 Mar 9;128(5):991-1002. doi: 10.1016/j.cell.2007.02.025. Cell. 2007. PMID: 17350581 Free article.
Modeling metastatic breast cancer in mice.
Jonkers J, Derksen PW. Jonkers J, et al. J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):191-203. doi: 10.1007/s10911-007-9050-8. J Mammary Gland Biol Neoplasia. 2007. PMID: 17587153 Free article. Review.
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J. Liu X, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. doi: 10.1073/pnas.0702969104. Epub 2007 Jul 11. Proc Natl Acad Sci U S A. 2007. PMID: 17626182 Free PMC article.
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.
Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van Tellingen O, Schouten JP, Jonkers J, Borst P. Rottenberg S, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12117-22. doi: 10.1073/pnas.0702955104. Epub 2007 Jul 11. Proc Natl Acad Sci U S A. 2007. PMID: 17626183 Free PMC article.
What makes tumors multidrug resistant?
Borst P, Jonkers J, Rottenberg S. Borst P, et al. Among authors: jonkers j. Cell Cycle. 2007 Nov 15;6(22):2782-7. doi: 10.4161/cc.6.22.4936. Epub 2007 Aug 23. Cell Cycle. 2007. PMID: 17998803 Review.
349 results