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Consensus engineering of sucrose phosphorylase: the outcome reflects the sequence input.

Aerts D, Verhaeghe T, Joosten HJ, Vriend G, Soetaert W, Desmet T. Aerts D, et al. Among authors: joosten hj. Biotechnol Bioeng. 2013 Oct;110(10):2563-72. doi: 10.1002/bit.24940. Epub 2013 May 7. Biotechnol Bioeng. 2013. PMID: 23613221

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A structural classification of carbohydrate epimerases: From mechanistic insights to practical applications.

Van Overtveldt S, Verhaeghe T, Joosten HJ, van den Bergh T, Beerens K, Desmet T. Van Overtveldt S, et al. Among authors: joosten hj. Biotechnol Adv. 2015 Dec;33(8):1814-28. doi: 10.1016/j.biotechadv.2015.10.010. Epub 2015 Oct 23. Biotechnol Adv. 2015. PMID: 26505535 Review.

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Increasing the thermostability of sucrose phosphorylase by a combination of sequence- and structure-based mutagenesis.

Cerdobbel A, De Winter K, Aerts D, Kuipers R, Joosten HJ, Soetaert W, Desmet T. Cerdobbel A, et al. Among authors: joosten hj. Protein Eng Des Sel. 2011 Nov;24(11):829-34. doi: 10.1093/protein/gzr042. Epub 2011 Sep 6. Protein Eng Des Sel. 2011. PMID: 21900303

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CorNet: Assigning function to networks of co-evolving residues by automated literature mining.

van den Bergh T, Tamo G, Nobili A, Tao Y, Tan T, Bornscheuer UT, Kuipers RKP, Vroling B, de Jong RM, Subramanian K, Schaap PJ, Desmet T, Nidetzky B, Vriend G, Joosten HJ. van den Bergh T, et al. Among authors: joosten hj. PLoS One. 2017 May 18;12(5):e0176427. doi: 10.1371/journal.pone.0176427. eCollection 2017. PLoS One. 2017. PMID: 28545124 Free PMC article.

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Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases.

Knight AM, Nobili A, van den Bergh T, Genz M, Joosten HJ, Albrecht D, Riedel K, Pavlidis IV, Bornscheuer UT. Knight AM, et al. Among authors: joosten hj. Appl Microbiol Biotechnol. 2017 Feb;101(4):1499-1507. doi: 10.1007/s00253-016-7940-7. Epub 2016 Oct 27. Appl Microbiol Biotechnol. 2017. PMID: 27787586

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3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities.

Kuipers RK, Joosten HJ, van Berkel WJ, Leferink NG, Rooijen E, Ittmann E, van Zimmeren F, Jochens H, Bornscheuer U, Vriend G, dos Santos VA, Schaap PJ. Kuipers RK, et al. Among authors: joosten hj. Proteins. 2010 Jul;78(9):2101-13. doi: 10.1002/prot.22725. Proteins. 2010. PMID: 20455266

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NewProt - a protein engineering portal.

Schwarte A, Genz M, Skalden L, Nobili A, Vickers C, Melse O, Kuipers R, Joosten HJ, Stourac J, Bendl J, Black J, Haase P, Baakman C, Damborsky J, Bornscheuer U, Vriend G, Venselaar H. Schwarte A, et al. Among authors: joosten hj. Protein Eng Des Sel. 2017 Jun 1;30(6):441-447. doi: 10.1093/protein/gzx024. Protein Eng Des Sel. 2017. PMID: 28475759

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Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily.

Lanfranchi E, Pavkov-Keller T, Koehler EM, Diepold M, Steiner K, Darnhofer B, Hartler J, Van Den Bergh T, Joosten HJ, Gruber-Khadjawi M, Thallinger GG, Birner-Gruenberger R, Gruber K, Winkler M, Glieder A. Lanfranchi E, et al. Among authors: joosten hj. Sci Rep. 2017 May 3;7:46738. doi: 10.1038/srep46738. Sci Rep. 2017. PMID: 28466867 Free PMC article.

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Simultaneous use of in silico design and a correlated mutation network as a tool to efficiently guide enzyme engineering.

Nobili A, Tao Y, Pavlidis IV, van den Bergh T, Joosten HJ, Tan T, Bornscheuer UT. Nobili A, et al. Among authors: joosten hj. Chembiochem. 2015 Mar 23;16(5):805-10. doi: 10.1002/cbic.201402665. Epub 2015 Feb 25. Chembiochem. 2015. PMID: 25711719

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Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications.

Steffen-Munsberg F, Vickers C, Kohls H, Land H, Mallin H, Nobili A, Skalden L, van den Bergh T, Joosten HJ, Berglund P, Höhne M, Bornscheuer UT. Steffen-Munsberg F, et al. Among authors: joosten hj. Biotechnol Adv. 2015 Sep-Oct;33(5):566-604. doi: 10.1016/j.biotechadv.2014.12.012. Epub 2015 Jan 7. Biotechnol Adv. 2015. PMID: 25575689 Review.

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