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Page 1
Protocol for generating mouse morula-like cells resembling 8- to 16-cell stage embryo cells.
Li H, Chang L, Huang J, Silva JCR. Li H, et al. Among authors: silva jcr. STAR Protoc. 2024 Jun 21;5(2):102934. doi: 10.1016/j.xpro.2024.102934. Epub 2024 Mar 29. STAR Protoc. 2024. PMID: 38555588 Free PMC article.
Generating cell types with properties of embryo cells with full developmental potential is of great biological importance. ...We then detail procedures for segregating MLCs into blastocyst cell fates and how to create embryo-like structures from them. This sy …
Generating cell types with properties of embryo cells with full developmental potential is of great biological importance. ... …
Self-renewing human naive pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.
Guo M, Wu J, Chen C, Wang X, Gong A, Guan W, Karvas RM, Wang K, Min M, Wang Y, Theunissen TW, Gao S, Silva JCR. Guo M, et al. Among authors: silva jcr. Nat Commun. 2024 Jan 22;15(1):668. doi: 10.1038/s41467-024-44969-x. Nat Commun. 2024. PMID: 38253551 Free PMC article.
Human naive pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. ...
Human naive pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to indu …
In vitro generation of mouse morula-like cells.
Li H, Chang L, Wu J, Huang J, Guan W, Bates LE, Stuart HT, Guo M, Zhang P, Huang B, Chen C, Zhang M, Chen J, Min M, Wu G, Hutchins AP, Silva JCR. Li H, et al. Among authors: silva jcr. Dev Cell. 2023 Nov 20;58(22):2510-2527.e7. doi: 10.1016/j.devcel.2023.09.013. Epub 2023 Oct 23. Dev Cell. 2023. PMID: 37875119 Free article.
Here we report the in vitro generation of mouse transient morula-like cells (MLCs) via the manipulation of signaling pathways. MLCs are molecularly distinct from embryonic stem cells (ESCs) and cluster instead with embryo 8- to 16-cell stage cells …
Here we report the in vitro generation of mouse transient morula-like cells (MLCs) via the manipulation of signaling pathways. MLCs a …
Reprogramming Cell Identity: Past Lessons, Challenges, and Future Directions.
Silva JCR. Silva JCR. Cell Reprogram. 2023 Oct;25(5):183-186. doi: 10.1089/cell.2023.0100. Cell Reprogram. 2023. PMID: 37847897
Reprogramming is traditionally defined as the fate conversion of a cell to a stage of increased developmental potential. In its broader meaning, the reprogramming term is also applied to all forms of cell fate conversion that do not follow a developmental trajectory …
Reprogramming is traditionally defined as the fate conversion of a cell to a stage of increased developmental potential. In its broad …
Tumor suppressors inhibit reprogramming of African spiny mouse ( Acomys) fibroblasts to induced pluripotent stem cells.
Sandoval AGW, Maden M, Bates LE, Silva JCR. Sandoval AGW, et al. Among authors: silva jcr. Wellcome Open Res. 2022 Aug 18;7:215. doi: 10.12688/wellcomeopenres.18034.1. eCollection 2022. Wellcome Open Res. 2022. PMID: 36060301 Free PMC article.
Background: The African spiny mouse ( Acomys) is an emerging mammalian model for scar-free regeneration, and further study of Acomys could advance the field of regenerative medicine. Isolation of pluripotent stem cells from Acomys would allow for development of tran …
Background: The African spiny mouse ( Acomys) is an emerging mammalian model for scar-free regeneration, and further study of Acomys could a …
Why it is important to study human-monkey embryonic chimeras in a dish.
De Los Angeles A, Regenberg A, Mascetti V, Benvenisty N, Church G, Deng H, Izpisua Belmonte JC, Ji W, Koplin J, Loh YH, Niu Y, Pei D, Pera M, Pho N, Pinzon-Arteaga C, Saitou M, Silva JCR, Tao T, Trounson A, Warrier T, Zambidis ET. De Los Angeles A, et al. Among authors: silva jcr. Nat Methods. 2022 Aug;19(8):914-919. doi: 10.1038/s41592-022-01571-7. Nat Methods. 2022. PMID: 35879609 Free PMC article.
OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
Bernard LD, Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, Tachtsidi A, Gil N, Owens N, Bates LE, Vandormael-Pournin S, Silva JCR, Ulitsky I, Cohen-Tannoudji M, Navarro P. Bernard LD, et al. Among authors: silva jcr. Nucleic Acids Res. 2022 Jul 22;50(13):7367-7379. doi: 10.1093/nar/gkac550. Nucleic Acids Res. 2022. PMID: 35762231 Free PMC article.
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. Accordingly, in undifferentiated and pluripotent mouse Embryonic Stem …
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contrib …
47 results