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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 1
2006 1
2007 1
2008 3
2009 3
2010 2
2011 3
2012 3
2013 3
2014 6
2017 2
2018 2
2019 4
2021 4
2022 2
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39 results
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Why it is important to study human-monkey embryonic chimeras in a dish.
De Los Angeles A, Regenberg A, Mascetti V, Benvenisty N, Church G, Deng H, Izpisua Belmonte JC, Ji W, Koplin J, Loh YH, Niu Y, Pei D, Pera M, Pho N, Pinzon-Arteaga C, Saitou M, Silva JCR, Tao T, Trounson A, Warrier T, Zambidis ET. De Los Angeles A, et al. Among authors: silva jcr. Nat Methods. 2022 Aug;19(8):914-919. doi: 10.1038/s41592-022-01571-7. Nat Methods. 2022. PMID: 35879609 No abstract available.
OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
Bernard LD, Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, Tachtsidi A, Gil N, Owens N, Bates LE, Vandormael-Pournin S, Silva JCR, Ulitsky I, Cohen-Tannoudji M, Navarro P. Bernard LD, et al. Among authors: silva jcr. Nucleic Acids Res. 2022 Jul 22;50(13):7367-7379. doi: 10.1093/nar/gkac550. Nucleic Acids Res. 2022. PMID: 35762231 Free PMC article.
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. Accordingly, in undifferentiated and pluripotent mouse Embryonic Stem
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contrib …
StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells.
Labouesse C, Tan BX, Agley CC, Hofer M, Winkel AK, Stirparo GG, Stuart HT, Verstreken CM, Mulas C, Mansfield W, Bertone P, Franze K, Silva JCR, Chalut KJ. Labouesse C, et al. Among authors: silva jcr. Nat Commun. 2021 Oct 21;12(1):6132. doi: 10.1038/s41467-021-26236-5. Nat Commun. 2021. PMID: 34675200 Free PMC article.
We validate StemBond hydrogels by showing that they provide an optimal system for culturing mouse and human pluripotent stem cells. We further show how soft StemBond hydrogels modulate stem cell function, partly through stiffness-sensitive ERK signalli …
We validate StemBond hydrogels by showing that they provide an optimal system for culturing mouse and human pluripotent stem cells
Auxin-degron system identifies immediate mechanisms of OCT4.
Bates LE, Alves MRP, Silva JCR. Bates LE, et al. Among authors: silva jcr. Stem Cell Reports. 2021 Jul 13;16(7):1818-1831. doi: 10.1016/j.stemcr.2021.05.016. Epub 2021 Jun 17. Stem Cell Reports. 2021. PMID: 34143975 Free PMC article.
The pluripotency factor OCT4 is essential for the maintenance of naive pluripotent stem cells in vitro and in vivo. However, the specific role of OCT4 in this process remains unknown. ...Our work establishes that, while OCT4 is required for the maintenance of the na …
The pluripotency factor OCT4 is essential for the maintenance of naive pluripotent stem cells in vitro and in vivo. However, t …
Sox2 modulation increases naïve pluripotency plasticity.
Tremble KC, Stirparo GG, Bates LE, Maskalenka K, Stuart HT, Jones K, Andersson-Rolf A, Radzisheuskaya A, Koo BK, Bertone P, Silva JCR. Tremble KC, et al. Among authors: silva jcr. iScience. 2021 Feb 6;24(3):102153. doi: 10.1016/j.isci.2021.102153. eCollection 2021 Mar 19. iScience. 2021. PMID: 33665571 Free PMC article.
Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low). ...Strikingly, upon …
Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent …
OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.
Stirparo GG, Kurowski A, Yanagida A, Bates LE, Strawbridge SE, Hladkou S, Stuart HT, Boroviak TE, Silva JCR, Nichols J. Stirparo GG, et al. Among authors: silva jcr. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2008890118. doi: 10.1073/pnas.2008890118. Proc Natl Acad Sci U S A. 2021. PMID: 33452132 Free PMC article.
To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics and quantitative immunofluorescence on control and OCT4 null blastocyst inner cell masses at two developmental stages. Surprisingly, …
To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics …
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR. Stuart HT, et al. Among authors: silva jcr. Cell Stem Cell. 2019 Sep 5;25(3):388-406.e8. doi: 10.1016/j.stem.2019.07.009. Epub 2019 Aug 15. Cell Stem Cell. 2019. PMID: 31422912 Free PMC article.
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct ro …
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are …
ZMYM2 inhibits NANOG-mediated reprogramming.
Lawrence M, Theunissen TW, Lombard P, Adams DJ, Silva JCR. Lawrence M, et al. Among authors: silva jcr. Wellcome Open Res. 2019 Jun 6;4:88. doi: 10.12688/wellcomeopenres.15250.1. eCollection 2019. Wellcome Open Res. 2019. PMID: 31363497 Free PMC article.
Results: In this work, we identified ZMYM2/ZFP198, which physically associates with NANOG as a key negative regulator of NANOG-mediated reprogramming of both epiblast stem cells and somatic cells. In addition, ZMYM2 impairs the self renewal of embryonic st
Results: In this work, we identified ZMYM2/ZFP198, which physically associates with NANOG as a key negative regulator of NANOG-mediated repr …
WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming.
Peñalosa-Ruiz G, Bousgouni V, Gerlach JP, Waarlo S, van de Ven JV, Veenstra TE, Silva JCR, van Heeringen SJ, Bakal C, Mulder KW, Veenstra GJC. Peñalosa-Ruiz G, et al. Among authors: silva jcr. Stem Cell Reports. 2019 Apr 9;12(4):743-756. doi: 10.1016/j.stemcr.2019.02.006. Epub 2019 Mar 14. Stem Cell Reports. 2019. PMID: 30880078 Free PMC article.
Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription factors. Despite significant effort, relatively little is known about the cellular requirements for reprogramming and how they affect the propert …
Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription facto …
Long-Term Perfusion Culture of Monoclonal Embryonic Stem Cells in 3D Hydrogel Beads for Continuous Optical Analysis of Differentiation.
Kleine-Brüggeney H, van Vliet LD, Mulas C, Gielen F, Agley CC, Silva JCR, Smith A, Chalut K, Hollfelder F. Kleine-Brüggeney H, et al. Among authors: silva jcr. Small. 2019 Feb;15(5):e1804576. doi: 10.1002/smll.201804576. Epub 2018 Dec 20. Small. 2019. PMID: 30570812
Developmental cell biology requires technologies in which the fate of single cells is followed over extended time periods, to monitor and understand the processes of self-renewal, differentiation, and reprogramming. ...The defined 3D environment emulates the natural …
Developmental cell biology requires technologies in which the fate of single cells is followed over extended time periods, to …
39 results