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53 results

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Page 1
Human stem cell-based embryo models: innovation, ethics, and policy.
Arias AM, Rivron N, Tajbakhsh S, Johnston J, Alev C, Bally-Cuif L, Böke E, Cavazza T, Cave E, Cyranoski D, David L, Esteban MA, Fu J, Geijsen N, de Graeff N, Hanna JH, Hopwood N, Inamdar MS, Lanner F, Leeners B, Liu Z, Jean Leon M, Minchiotti G, Moris N, Munsie M, Niakan KK, Pourquie O, Pasque V, Pera M, Peng Y, Petropoulos S, Ramanathan S, Rossant J, Rugg-Gunn P, Saitou M, Sermon K, Silva J, Theunissen T, Turco M, Wallingford J, Wang H, Warmflash A, Wu J, Yu L. Arias AM, et al. Among authors: silva j. Hum Reprod. 2026 Mar 24:deag035. doi: 10.1093/humrep/deag035. Online ahead of print. Hum Reprod. 2026. PMID: 41875051
The aim of this White Paper is to establish a foundational framework for research, technological development, and regulation in the emerging field of stem cell-based embryo models (SCBEMs). These models, generated from Pluripotent Stem Cells, are desig …
The aim of this White Paper is to establish a foundational framework for research, technological development, and regulation in the emerging …
Engineering chromatin loops to control cell fate: LoopID reveals catalytic-independent functions of epigenetic regulators.
Li H, Silva JCR. Li H, et al. Among authors: silva jcr. Cell Transplant. 2026 Jan-Dec;35:9636897261424577. doi: 10.1177/09636897261424577. Epub 2026 Feb 17. Cell Transplant. 2026. PMID: 41700022 Free PMC article.
Enhancer-promoter (E-P) interactions are central to cell-type-specific transcriptional programs, yet the molecular machinery that establishes and maintains these loops has remained poorly defined. ...Using LoopID, they profile the "looposome" in mouse embryonic stem …
Enhancer-promoter (E-P) interactions are central to cell-type-specific transcriptional programs, yet the molecular machinery that est …
A two-tier framework for responsible research on human embryo models.
De Los Angeles A, Bayne T, Benvenisty N, Deng H, Fujita M, Ji W, Latham S, Li T, Liu P, Loh YH, Lunshof J, Pei D, Pho N, Silva JCR, Ka Ki Tam TT, Tao T, Trounson A, Xu S, Yu L, Koplin J, Regenberg A, Sugaya K, Savulescu J, Zernicka-Goetz M, Lovell-Badge R. De Los Angeles A, et al. Among authors: silva jcr. Cell. 2026 Jan 22;189(2):348-355. doi: 10.1016/j.cell.2025.12.006. Cell. 2026. PMID: 41576917
Human stem-cell-based embryo models (SCBEMs) imperfectly mimic some-but not all-features of early human development. ...
Human stem-cell-based embryo models (SCBEMs) imperfectly mimic some-but not all-features of early human development. ...
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling.
Chen C, Wu J, Wang X, Chang L, Wang K, Wu K, Guo M, Li H, Sun F, Jiang X, Ma Y, Pan G, Xiao Z, Silva JCR. Chen C, et al. Among authors: silva jcr. Cell Stem Cell. 2025 Oct 2;32(10):1528-1544.e10. doi: 10.1016/j.stem.2025.08.011. Epub 2025 Sep 16. Cell Stem Cell. 2025. PMID: 40961945
Here, we investigate whether STAT3 activation can reprogram pluripotent stem cells (PSCs) into early fates that self-organize into embryo models. Using a medium enhancing STAT3 activity (SAM), PSCs reprogram within 60 h into hypoblast, trophectoderm, naive epiblast, …
Here, we investigate whether STAT3 activation can reprogram pluripotent stem cells (PSCs) into early fates that self-organize …
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state.
Gao Y, Li M, Guan W, Guo W, Wei S, Yan F, Han W, Zhang X, Yin T, Dang Y, Li H, Silva JCR, Zhang J. Gao Y, et al. Among authors: silva jcr. Nat Cell Biol. 2025 Sep;27(9):1572-1586. doi: 10.1038/s41556-025-01732-8. Epub 2025 Aug 14. Nat Cell Biol. 2025. PMID: 40813453
The first embryonic cell differentiation in mice segregates the trophectoderm and the inner cell mass. Successful derivation of mouse trophoblast stem cells (TSCs) and trophectoderm stem cells (TESCs) has greatly facilitated the understan …
The first embryonic cell differentiation in mice segregates the trophectoderm and the inner cell mass. Successful derivation o …
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells.
Li H, Guan W, Huang J, Shen P, Wu J, Luo H, Yang Y, Ning S, Chang L, Zhao H, Chen C, Gao Y, Chen Y, Yang X, Costa Y, Cai CL, Pei D, Peng G, Wu G, Chen J, Zhang J, Jing N, Silva JCR. Li H, et al. Among authors: silva jcr. Cell. 2025 Oct 16;188(21):5912-5930.e20. doi: 10.1016/j.cell.2025.07.018. Epub 2025 Aug 7. Cell. 2025. PMID: 40780195 Free article.
Here, we employ a small-molecule-only approach to induce mouse embryonic stem cells into 8- to 16-cell-like embryo founder cells, enabling the generation of a complete embryo model. These founder cells specify all blastocyst lineages, both embry …
Here, we employ a small-molecule-only approach to induce mouse embryonic stem cells into 8- to 16-cell-like embryo foun …
Protocol for generating mouse morula-like cells resembling 8- to 16-cell stage embryo cells.
Li H, Chang L, Huang J, Silva JCR. Li H, et al. Among authors: silva jcr. STAR Protoc. 2024 Jun 21;5(2):102934. doi: 10.1016/j.xpro.2024.102934. Epub 2024 Mar 29. STAR Protoc. 2024. PMID: 38555588 Free PMC article.
Generating cell types with properties of embryo cells with full developmental potential is of great biological importance. ...We then detail procedures for segregating MLCs into blastocyst cell fates and how to create embryo-like structures from them. This sy …
Generating cell types with properties of embryo cells with full developmental potential is of great biological importance. ... …
Self-renewing human naive pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.
Guo M, Wu J, Chen C, Wang X, Gong A, Guan W, Karvas RM, Wang K, Min M, Wang Y, Theunissen TW, Gao S, Silva JCR. Guo M, et al. Among authors: silva jcr. Nat Commun. 2024 Jan 22;15(1):668. doi: 10.1038/s41467-024-44969-x. Nat Commun. 2024. PMID: 38253551 Free PMC article.
Human naive pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. ...
Human naive pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to indu …
53 results