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Year Number of Results
2002 1
2003 1
2004 1
2006 1
2007 1
2008 3
2009 3
2010 2
2011 3
2012 3
2013 3
2014 6
2017 2
2018 2
2019 4
2021 2
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Page 1
WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming.
Peñalosa-Ruiz G, Bousgouni V, Gerlach JP, Waarlo S, van de Ven JV, Veenstra TE, Silva JCR, van Heeringen SJ, Bakal C, Mulder KW, Veenstra GJC. Peñalosa-Ruiz G, et al. Among authors: silva jcr. Stem Cell Reports. 2019 Apr 9;12(4):743-756. doi: 10.1016/j.stemcr.2019.02.006. Epub 2019 Mar 14. Stem Cell Reports. 2019. PMID: 30880078 Free PMC article.
Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription factors. Despite significant effort, relatively little is known about the cellular requirements for reprogramming and how they affect the propert …
Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription facto …
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T. Christophorou MA, et al. Among authors: silva jc. Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26. Nature. 2014. PMID: 24463520 Free PMC article.
PADI4 (also called PAD4 or PADV), the only PADI with a nuclear localization signal, was previously shown to act in myeloid cells where it mediates profound chromatin decondensation during the innate immune response to infection. ...Padi4 is part of the pluripotency transcr …
PADI4 (also called PAD4 or PADV), the only PADI with a nuclear localization signal, was previously shown to act in myeloid cells wher …
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR. Stuart HT, et al. Among authors: silva jcr. Cell Stem Cell. 2019 Sep 5;25(3):388-406.e8. doi: 10.1016/j.stem.2019.07.009. Epub 2019 Aug 15. Cell Stem Cell. 2019. PMID: 31422912 Free PMC article.
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct ro …
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are …
One-step generation of conditional and reversible gene knockouts.
Andersson-Rolf A, Mustata RC, Merenda A, Kim J, Perera S, Grego T, Andrews K, Tremble K, Silva JC, Fink J, Skarnes WC, Koo BK. Andersson-Rolf A, et al. Among authors: silva jc. Nat Methods. 2017 Mar;14(3):287-289. doi: 10.1038/nmeth.4156. Epub 2017 Jan 30. Nat Methods. 2017. PMID: 28135257 Free PMC article.
Loss-of-function studies are key for investigating gene function, and CRISPR technology has made genome editing widely accessible in model organisms and cells. However, conditional gene inactivation in diploid cells is still difficult to achieve. Here, we present CR …
Loss-of-function studies are key for investigating gene function, and CRISPR technology has made genome editing widely accessible in model o …
Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males.
Sousa EJ, Stuart HT, Bates LE, Ghorbani M, Nichols J, Dietmann S, Silva JCR. Sousa EJ, et al. Among authors: silva jcr. Cell Stem Cell. 2018 Jun 1;22(6):919-928.e6. doi: 10.1016/j.stem.2018.05.001. Epub 2018 May 24. Cell Stem Cell. 2018. PMID: 29804891 Free PMC article.
It is not clear whether prevention of X chromosome inactivation (XCI) is mediated by gene networks that preserve the naive state. Here, we show that robust naive pluripotent stem cell (nPSC) self-renewal represses expression of Xist, the master regulator of XCI. ...
It is not clear whether prevention of X chromosome inactivation (XCI) is mediated by gene networks that preserve the naive state. Here, we s …
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.
Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J. Costa Y, et al. Among authors: silva jc. Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10. Nature. 2013. PMID: 23395962 Free PMC article.
Using enhanced purification techniques and a stringent computational algorithm, we identify 27 high-confidence protein interaction partners of NANOG in mouse embryonic stem cells. These consist of 19 previously unknown partners of NANOG that have not been reported b …
Using enhanced purification techniques and a stringent computational algorithm, we identify 27 high-confidence protein interaction partners …
Do all roads lead to Oct4? the emerging concepts of induced pluripotency.
Radzisheuskaya A, Silva JC. Radzisheuskaya A, et al. Among authors: silva jc. Trends Cell Biol. 2014 May;24(5):275-84. doi: 10.1016/j.tcb.2013.11.010. Epub 2013 Dec 23. Trends Cell Biol. 2014. PMID: 24370212 Free PMC article. Review.
Pluripotent cells have the potential to differentiate into all of the cell types of an animal. ...Among these, Oct4 plays an essential role both in the development of pluripotent cells in the embryo and in the self-renewal of its in vitro counterpart, embryon …
Pluripotent cells have the potential to differentiate into all of the cell types of an animal. ...Among these, Oct4 plays an e …
Long-Term Perfusion Culture of Monoclonal Embryonic Stem Cells in 3D Hydrogel Beads for Continuous Optical Analysis of Differentiation.
Kleine-Brüggeney H, van Vliet LD, Mulas C, Gielen F, Agley CC, Silva JCR, Smith A, Chalut K, Hollfelder F. Kleine-Brüggeney H, et al. Among authors: silva jcr. Small. 2019 Feb;15(5):e1804576. doi: 10.1002/smll.201804576. Epub 2018 Dec 20. Small. 2019. PMID: 30570812
Developmental cell biology requires technologies in which the fate of single cells is followed over extended time periods, to monitor and understand the processes of self-renewal, differentiation, and reprogramming. ...The defined 3D environment emulates the natural …
Developmental cell biology requires technologies in which the fate of single cells is followed over extended time periods, to …
MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner.
dos Santos RL, Tosti L, Radzisheuskaya A, Caballero IM, Kaji K, Hendrich B, Silva JC. dos Santos RL, et al. Among authors: silva jc. Cell Stem Cell. 2014 Jul 3;15(1):102-10. doi: 10.1016/j.stem.2014.04.019. Epub 2014 May 15. Cell Stem Cell. 2014. PMID: 24835571 Free PMC article.
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for embryonic development and pluripotent stem cell differentiation. In this study, we investigated whether NuRD is also involved in the reverse biological process of induction of pluripotency in …
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for embryonic development and pluripotent stem cell diff …
Nanog is dispensable for the generation of induced pluripotent stem cells.
Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K. Schwarz BA, et al. Among authors: silva jc. Curr Biol. 2014 Feb 3;24(3):347-50. doi: 10.1016/j.cub.2013.12.050. Epub 2014 Jan 23. Curr Biol. 2014. PMID: 24461999 Free PMC article.
Cellular reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) can be achieved through forced expression of the transcription factors Oct4, Klf4, Sox2, and c-Myc (OKSM) [1-4]. ...Although Nanog expression is not required for the maintenan …
Cellular reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) can be achieved through forced expr …
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