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TGF-beta signaling, tumor microenvironment and tumor progression: the butterfly effect.
Joshi A, Cao D. Joshi A, et al. Front Biosci (Landmark Ed). 2010 Jan 1;15:180-94. doi: 10.2741/3614. Front Biosci (Landmark Ed). 2010. PMID: 20036814 Review.
TGF-beta plays a crucial role in the cancer initiation and progression through tumor cell autonomous signaling and interactions with tumor microenvironment, but is featured with a butterfly effect upon the stages of tumorigenesis. TGF-beta signaling acts as a
TGF-beta plays a crucial role in the cancer initiation and progression through tumor cell autonomous signaling and interactions with …
Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.
Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A. Flister MJ, et al. Breast Cancer Res Treat. 2017 Aug;165(1):53-64. doi: 10.1007/s10549-017-4311-8. Epub 2017 May 31. Breast Cancer Res Treat. 2017. PMID: 28567545 Free PMC article.
RESULTS: Breast cancer xenografts implanted in SS.BN3(IL2Rγ) (consomic) had significant tumor growth inhibition compared with SS(IL2Rγ) (parental control), despite a paradoxical increase in the density of blood vessels in the SS.BN3(IL2Rγ) tumors. ...Gene expression analys …
RESULTS: Breast cancer xenografts implanted in SS.BN3(IL2Rγ) (consomic) had significant tumor growth inhibition compared with SS(IL2Rγ) (par …
Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.
Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ. Plasterer C, et al. Breast Cancer Res Treat. 2019 Aug;177(1):77-91. doi: 10.1007/s10549-019-05307-8. Epub 2019 Jun 4. Breast Cancer Res Treat. 2019. PMID: 31165373
Here, we identified Neuronatin (NNAT) as a novel antiproliferative modifier of estrogen receptor-alpha (ER+) breast cancer. EXPERIMENTAL DESIGN: Genomic regions harboring breast cancer modifiers were identified by congenic mapping in a rat model of carcinogen-induce …
Here, we identified Neuronatin (NNAT) as a novel antiproliferative modifier of estrogen receptor-alpha (ER+) breast cancer. EXPERIMEN …
Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy.
Sharma G, Jagtap JM, Parchur AK, Gogineni VR, Ran S, Bergom C, White SB, Flister MJ, Joshi A. Sharma G, et al. Theranostics. 2020 Apr 6;10(12):5368-5383. doi: 10.7150/thno.41171. eCollection 2020. Theranostics. 2020. PMID: 32373218 Free PMC article.
The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes.
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith A, Adidharma P, Steel C, Richardson S, Pease L, Danilenko M, Crosier S, Joshi A, Wharton S, Jacques T, Pizer B, Michalski A, Williamson D, Bailey S, Clifford SC. Hicks D, et al. Among authors: joshi a. Neuropathol Appl Neurobiol. 2020 Aug 11. doi: 10.1111/nan.12656. Online ahead of print. Neuropathol Appl Neurobiol. 2020. PMID: 32779246
Use of a sternocleidomastoid rotational and cervical-fascial advancement flap for closure of a persistent mastoid cutaneous fistula.
Tsitsiou Y, Mantelakis A, Joshi A. Tsitsiou Y, et al. Among authors: joshi a. J Laryngol Otol. 2020 Aug 10:1-3. doi: 10.1017/S0022215120001498. Online ahead of print. J Laryngol Otol. 2020. PMID: 32772935
Immunohistochemical expression of cyclin D1 in invasive breast carcinoma and its correlation with clinicopathological parameters.
Lengare PV, Sinai Khandeparkar SG, Joshi AR, Gogate BP, Solanke SG, Gore SH. Lengare PV, et al. Among authors: joshi ar. Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):376-381. doi: 10.4103/IJPM.IJPM_106_20. Indian J Pathol Microbiol. 2020. PMID: 32769325
Multi-"-Omics" Profiling in Patients With Quiescent Inflammatory Bowel Disease Identifies Biomarkers Predicting Relapse.
Borren NZ, Plichta D, Joshi AD, Bonilla G, Sadreyev R, Vlamakis H, Xavier RJ, Ananthakrishnan AN. Borren NZ, et al. Among authors: joshi ad. Inflamm Bowel Dis. 2020 Aug 7:izaa183. doi: 10.1093/ibd/izaa183. Online ahead of print. Inflamm Bowel Dis. 2020. PMID: 32766830
Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.
Thomas M, Sakoda LC, Hoffmeister M, Rosenthal EA, Lee JK, van Duijnhoven FJB, Platz EA, Wu AH, Dampier CH, de la Chapelle A, Wolk A, Joshi AD, Burnett-Hartman A, Gsur A, Lindblom A, Castells A, Win AK, Namjou B, Van Guelpen B, Tangen CM, He Q, Li CI, Schafmayer C, Joshu CE, Ulrich CM, Bishop DT, Buchanan DD, Schaid D, Drew DA, Muller DC, Duggan D, Crosslin DR, Albanes D, Giovannucci EL, Larson E, Qu F, Mentch F, Giles GG, Hakonarson H, Hampel H, Stanaway IB, Figueiredo JC, Huyghe JR, Minnier J, Chang-Claude J, Hampe J, Harley JB, Visvanathan K, Curtis KR, Offit K, Li L, Le Marchand L, Vodickova L, Gunter MJ, Jenkins MA, Slattery ML, Lemire M, Woods MO, Song M, Murphy N, Lindor NM, Dikilitas O, Pharoah PDP, Campbell PT, Newcomb PA, Milne RL, MacInnis RJ, Castellví-Bel S, Ogino S, Berndt SI, Bézieau S, Thibodeau SN, Gallinger SJ, Zaidi SH, Harrison TA, Keku TO, Hudson TJ, Vymetalkova V, Moreno V, Martín V, Arndt V, Wei WQ, Chung W, Su YR, Hayes RB, White E, Vodicka P, Casey G, Gruber SB, Schoen RE, Chan AT, Potter JD, Brenner H, Jarvik GP, Corley DA, Peters U, Hsu L. Thomas M, et al. Among authors: joshi ad. Am J Hum Genet. 2020 Jul 29:S0002-9297(20)30236-6. doi: 10.1016/j.ajhg.2020.07.006. Online ahead of print. Am J Hum Genet. 2020. PMID: 32758450
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