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Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Khoury N, Pizzo ME, Discenza CB, Joy D, Tatarakis D, Todorov MI, Negwer M, Ha C, De Melo GL, Sarrafha L, Simon MJ, Chan D, Chau R, Chew KS, Chow J, Clemens A, Robles-Colmenares Y, Dugas JC, Duque J, Kaltenecker D, Kane H, Leung A, Lozano E, Moshkforoush A, Roche E, Sandmann T, Tong M, Xa K, Zhou Y, Lewcock JW, Ertürk A, Thorne RG, Calvert MEK, Yu Zuchero YJ. Khoury N, et al. Among authors: joy d. Nat Commun. 2026 Apr 15;17(1):3515. doi: 10.1038/s41467-026-71806-0. Nat Commun. 2026. PMID: 41986322 Free PMC article. No abstract available.
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Torres VO, Pizzo ME, Chan D, Dugas JC, Huynh D, Joy D, Liang EK, Sarrafha L, Becerra I, Chau R, Chew KS, Chow J, Discenza CB, Earr TK, Furaso L, Khoury N, Lechtenberg KJ, Leung AW, Nguyen HN, Ojo ES, Roche E, Simon MJ, Solanoy H, Tong M, Tong RK, Henne K, Lewcock JW, Watts RJ, Calvert ME, Thorne RG, Zuchero YJY. Torres VO, et al. Among authors: joy d. J Cereb Blood Flow Metab. 2026 Jan;46(1):20-35. doi: 10.1177/0271678X251361997. Epub 2025 Aug 16. J Cereb Blood Flow Metab. 2026. PMID: 40817783 Free PMC article.
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Among authors: joy d. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Wells RC, Akkapeddi P, Chan D, Joy D, Moshkforoush A, Chau R, Chow J, Cherf GM, Chien EYT, Clemens A, Pizzo ME, Qerqez AN, Tran T, Becerra I, Dugas JC, Duque J, Earr TK, Huynh D, Kim DJ, Wing-Sze Leung A, Liang E, Nguyen HN, Robles-Colmenares Y, Kane H, Roche E, Sacayon P, Xa K, Solanoy H, Dennis MS, Lewcock JW, Watts RJ, Kariolis MS, Thorne RG, Koth CM, Calvert MEK, Yu Zuchero YJ, Chew KS. Wells RC, et al. Among authors: joy d. Cell Rep. 2025 Aug 26;44(8):116038. doi: 10.1016/j.celrep.2025.116038. Epub 2025 Jul 22. Cell Rep. 2025. PMID: 40705600 Free article.
152 results