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Toxic Electrophiles Induce Expression of the Multidrug Efflux Pump MexEF-OprN in Pseudomonas aeruginosa through a Novel Transcriptional Regulator, CmrA.
Juarez P, Jeannot K, Plésiat P, Llanes C. Juarez P, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00585-17. doi: 10.1128/AAC.00585-17. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28507116 Free PMC article.
Transcriptomic experiments demonstrated that CmrA positively regulates a small set of 11 genes, including PA14_38020 (homolog of PA2048), which is required for the MexS/T-dependent activation of mexEF-oprN PA2048 codes for a protein sharing conserved domains with the quinol monooxygenase YgiN from Escherichia coli Interestingly, exposure of strain PA14 to toxic electrophilic molecules (glyoxal, methylglyoxal, and cinnamaldehyde) strongly activates the CmrA pathway and upregulates MexEF-OprN and, thus, increases the resistance of P. aeruginosa to the pump substrates. ...
Transcriptomic experiments demonstrated that CmrA positively regulates a small set of 11 genes, including PA14_38020 (homolog of PA2048), wh …
Rheumatoid vasculitis: study of 41 cases.
Olivé A, Riveros A, Juárez P, Morales-Ivorra I, Holgado S, Narváez J. Olivé A, et al. Among authors: Juarez P. Med Clin (Barc). 2020 Mar 5:S0025-7753(20)30134-2. doi: 10.1016/j.medcli.2020.01.024. Online ahead of print. Med Clin (Barc). 2020. PMID: 32147187 English, Spanish.
Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium.
Bakshi S, Sanz Garcia R, Van der Weken H, Tharad A, Pandey S, Juarez P, Virdi V, Devriendt B, Cox E, Depicker A. Bakshi S, et al. Among authors: Juarez P. J Control Release. 2020 Jan 22;321:416-429. doi: 10.1016/j.jconrel.2020.01.033. Online ahead of print. J Control Release. 2020. PMID: 31981657
International Nosocomial Infection Control Consortium (INICC) report, data summary of 45 countries for 2012-2017: Device-associated module.
Rosenthal VD, Bat-Erdene I, Gupta D, Belkebir S, Rajhans P, Zand F, Myatra SN, Afeef M, Tanzi VL, Muralidharan S, Gurskis V, Al-Abdely HM, El-Kholy A, AlKhawaja SAA, Sen S, Mehta Y, Rai V, Hung NV, Sayed AF, Guerrero-Toapanta FM, Elahi N, Morfin-Otero MDR, Somabutr S, De-Carvalho BM, Magdarao MS, Velinova VA, Quesada-Mora AM, Anguseva T, Ikram A, Aguilar-de-Moros D, Duszynska W, Mejia N, Horhat FG, Belskiy V, Mioljevic V, Di-Silvestre G, Furova K, Gamar-Elanbya MO, Gupta U, Abidi K, Raka L, Guo X, Luque-Torres MT, Jayatilleke K, Ben-Jaballah N, Gikas A, Sandoval-Castillo HR, Trotter A, Valderrama-Beltrán SL, Leblebicioglu H; International Nosocomial Infection Control Consortium. Rosenthal VD, et al. Am J Infect Control. 2020 Apr;48(4):423-432. doi: 10.1016/j.ajic.2019.08.023. Epub 2019 Oct 29. Am J Infect Control. 2020. PMID: 31676155
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