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Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett. 2018 Dec 3;10(1):80-85. doi: 10.1021/acsmedchemlett.8b00461. eCollection 2019 Jan 10.
ACS Med Chem Lett. 2018.
PMID: 30655951
Free PMC article.
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.
Casimiro-Garcia A, Trujillo JI, Vajdos F, Juba B, Banker ME, Aulabaugh A, Balbo P, Bauman J, Chrencik J, Coe JW, Czerwinski R, Dowty M, Knafels JD, Kwon S, Leung L, Liang S, Robinson RP, Telliez JB, Unwalla R, Yang X, Thorarensen A.
Casimiro-Garcia A, et al. Among authors: juba b.
J Med Chem. 2018 Dec 13;61(23):10665-10699. doi: 10.1021/acs.jmedchem.8b01308. Epub 2018 Nov 30.
J Med Chem. 2018.
PMID: 30423248
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Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.
Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB.
Li J, et al. Among authors: juba bm.
ACS Chem Biol. 2017 Dec 15;12(12):2970-2974. doi: 10.1021/acschembio.7b00683. Epub 2017 Nov 13.
ACS Chem Biol. 2017.
PMID: 29088528
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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
Thorarensen A, Dowty ME, Banker ME, Juba B, Jussif J, Lin T, Vincent F, Czerwinski RM, Casimiro-Garcia A, Unwalla R, Trujillo JI, Liang S, Balbo P, Che Y, Gilbert AM, Brown MF, Hayward M, Montgomery J, Leung L, Yang X, Soucy S, Hegen M, Coe J, Langille J, Vajdos F, Chrencik J, Telliez JB.
Thorarensen A, et al. Among authors: juba b.
J Med Chem. 2017 Mar 9;60(5):1971-1993. doi: 10.1021/acs.jmedchem.6b01694. Epub 2017 Feb 16.
J Med Chem. 2017.
PMID: 28139931
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ATP-mediated kinome selectivity: the missing link in understanding the contribution of individual JAK Kinase isoforms to cellular signaling.
Thorarensen A, Banker ME, Fensome A, Telliez JB, Juba B, Vincent F, Czerwinski RM, Casimiro-Garcia A.
Thorarensen A, et al. Among authors: juba b.
ACS Chem Biol. 2014 Jul 18;9(7):1552-8. doi: 10.1021/cb5002125. Epub 2014 May 28.
ACS Chem Biol. 2014.
PMID: 24814050
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Apoptotic markers in photoinduced cutaneous carcinoma.
Abu Juba B, Şovrea A, Crişan D, Melincovici C, Coneac A, Badea M, Crişan M.
Abu Juba B, et al.
Rom J Morphol Embryol. 2013;54(3 Suppl):741-7.
Rom J Morphol Embryol. 2013.
PMID: 24322021
Free article.
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Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion.
Flanagan L, Packman K, Juba B, O'Neill S, Tenniswood M, Welsh J.
Flanagan L, et al. Among authors: juba b.
J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):181-92. doi: 10.1016/s0960-0760(03)00028-1.
J Steroid Biochem Mol Biol. 2003.
PMID: 12711002
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