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342 results
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siRNA and innate immunity.
Robbins M, Judge A, MacLachlan I. Robbins M, et al. Among authors: judge a. Oligonucleotides. 2009 Jun;19(2):89-102. doi: 10.1089/oli.2009.0180. Oligonucleotides. 2009. PMID: 19441890 Review.
Protection against lethal Marburg virus infection mediated by lipid encapsulated small interfering RNA.
Ursic-Bedoya R, Mire CE, Robbins M, Geisbert JB, Judge A, MacLachlan I, Geisbert TW. Ursic-Bedoya R, et al. Among authors: judge a. J Infect Dis. 2014 Feb 15;209(4):562-70. doi: 10.1093/infdis/jit465. Epub 2013 Aug 29. J Infect Dis. 2014. PMID: 23990568 Free PMC article.
Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation.
Robbins M, Judge A, Ambegia E, Choi C, Yaworski E, Palmer L, McClintock K, MacLachlan I. Robbins M, et al. Among authors: judge a. Hum Gene Ther. 2008 Oct;19(10):991-9. doi: 10.1089/hum.2008.131. Hum Gene Ther. 2008. PMID: 18713023
Overcoming the innate immune response to small interfering RNA.
Judge A, MacLachlan I. Judge A, et al. Hum Gene Ther. 2008 Feb;19(2):111-24. doi: 10.1089/hum.2007.179. Hum Gene Ther. 2008. PMID: 18230025 Review.
2'-O-methyl-modified RNAs act as TLR7 antagonists.
Robbins M, Judge A, Liang L, McClintock K, Yaworski E, MacLachlan I. Robbins M, et al. Among authors: judge a. Mol Ther. 2007 Sep;15(9):1663-9. doi: 10.1038/sj.mt.6300240. Epub 2007 Jun 19. Mol Ther. 2007. PMID: 17579574
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.
Judge AD, Robbins M, Tavakoli I, Levi J, Hu L, Fronda A, Ambegia E, McClintock K, MacLachlan I. Judge AD, et al. J Clin Invest. 2009 Mar;119(3):661-73. doi: 10.1172/JCI37515. Epub 2009 Feb 23. J Clin Invest. 2009. PMID: 19229107 Free PMC article.
RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. Zimmermann TS, et al. Among authors: judge ad. Nature. 2006 May 4;441(7089):111-4. doi: 10.1038/nature04688. Epub 2006 Mar 26. Nature. 2006. PMID: 16565705
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA.
Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Judge AD, et al. Nat Biotechnol. 2005 Apr;23(4):457-62. doi: 10.1038/nbt1081. Epub 2005 Mar 20. Nat Biotechnol. 2005. PMID: 15778705
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.
Judge AD, Bola G, Lee AC, MacLachlan I. Judge AD, et al. Mol Ther. 2006 Mar;13(3):494-505. doi: 10.1016/j.ymthe.2005.11.002. Epub 2005 Dec 15. Mol Ther. 2006. PMID: 16343994
Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.
Lee YH, Seo D, Choi KJ, Andersen JB, Won MA, Kitade M, Gómez-Quiroz LE, Judge AD, Marquardt JU, Raggi C, Conner EA, MacLachlan I, Factor VM, Thorgeirsson SS. Lee YH, et al. Among authors: judge ad. Cancer Res. 2014 Sep 1;74(17):4752-61. doi: 10.1158/0008-5472.CAN-13-3531. Epub 2014 Jun 23. Cancer Res. 2014. PMID: 24958469 Free PMC article.
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