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Year Number of Results
2015 3
2016 3
2017 4
2018 5
2019 3
2020 2
2021 3
2022 4
2023 4
2024 3
2025 5
2026 5

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38 results

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Page 1
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. Alterman JF, et al. Nat Biotechnol. 2019 Aug;37(8):884-894. doi: 10.1038/s41587-019-0205-0. Epub 2019 Aug 2. Nat Biotechnol. 2019. PMID: 31375812 Free PMC article.
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones.
Yamada K, Hariharan VN, Caiazzi J, Miller R, Ferguson CM, Sapp E, Fakih HH, Tang Q, Yamada N, Furgal RC, Paquette JD, Biscans A, Bramato BM, McHugh N, Summers A, Lochmann C, Godinho BMDC, Hildebrand S, Jackson SO, Echeverria D, Hassler MR, Alterman JF, DiFiglia M, Aronin N, Khvorova A. Yamada K, et al. Among authors: alterman jf. Nat Biotechnol. 2025 Jun;43(6):904-913. doi: 10.1038/s41587-024-02336-7. Epub 2024 Aug 1. Nat Biotechnol. 2025. PMID: 39090305
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.
Tang Q, Fakih HH, Zain Ui Abideen M, Hildebrand SR, Afshari K, Gross KY, Sousa J, Maebius AS, Bartholdy C, Søgaard PP, Jackerott M, Hariharan V, Summers A, Fan X, Okamura K, Monopoli KR, Cooper DA, Echeverria D, Bramato B, McHugh N, Furgal RC, Dresser K, Winter SJ, Biscans A, Chuprin J, Haddadi NS, Sherman S, Yıldız-Altay Ü, Rashighi M, Richmond JM, Bouix-Peter C, Blanchard C, Clauss A, Alterman JF, Khvorova A, Harris JE. Tang Q, et al. Among authors: alterman jf. Nat Commun. 2023 Nov 4;14(1):7099. doi: 10.1038/s41467-023-42714-4. Nat Commun. 2023. PMID: 37925520 Free PMC article.
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.
Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Davis SM, et al. Among authors: alterman jf. Nucleic Acids Res. 2025 Jun 20;53(12):gkaf479. doi: 10.1093/nar/gkaf479. Nucleic Acids Res. 2025. PMID: 40548938 Free PMC article.
Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.
Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Fakih HH, et al. Among authors: alterman jf. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1374. doi: 10.1093/nar/gkaf1374. Nucleic Acids Res. 2025. PMID: 41432033 Free PMC article.
Divalent siRNA for prion disease.
Gentile JE, Corridon TL, Serack FE, Echeverria D, Kennedy ZC, Gallant-Behm CL, Hassler MR, Kinberger GA, Kelemen MN, Kamath NG, Lian Y, Gross KY, Miller R, DeSouza-Lenz K, Howard M, Guzman K, Chan N, Laversenne V, Curtis DT, Fettes K, Lemaitre M, Jackson AL, Yamada K, Alterman JF, Coffey AA, Minikel EV, Khvorova A, Vallabh SM. Gentile JE, et al. Among authors: alterman jf. bioRxiv [Preprint]. 2026 Mar 5:2024.12.05.627039. doi: 10.1101/2024.12.05.627039. bioRxiv. 2026. PMID: 41867745 Free PMC article. Preprint.
A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases.
Tang Q, Fakih HH, Gross KY, Winter SJ, Bramato BM, Yıldız-Altay Ü, Chang BK, Echeverria D, Jackson SO, McHugh N, Srnka A, Alterman JF, Almela RM, Kudej RK, London CA, Richmond JM, Harris JE, Khvorova A. Tang Q, et al. Among authors: alterman jf. ACS Pharmacol Transl Sci. 2025 Mar 24;8(6):1526-1535. doi: 10.1021/acsptsci.4c00594. eCollection 2025 Jun 13. ACS Pharmacol Transl Sci. 2025. PMID: 40534660 Free PMC article.
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo.
O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. O'Reilly D, et al. Among authors: alterman jf. Nucleic Acids Res. 2026 Jan 5;54(1):gkaf1438. doi: 10.1093/nar/gkaf1438. Nucleic Acids Res. 2026. PMID: 41521659 Free PMC article.
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin.
Tang Q, Gross KY, Fakih HH, Jackson SO, Zain U I Abideen M, Monopoli KR, Blanchard C, Bouix-Peter C, Portal T, Harris JE, Khvorova A, Alterman JF. Tang Q, et al. Among authors: alterman jf. Mol Ther Nucleic Acids. 2024 Jan 9;35(1):102117. doi: 10.1016/j.omtn.2024.102117. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38304729 Free PMC article.
38 results