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Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.
Governa V, de Oliveira KG, Bång-Rudenstam A, Offer S, Cerezo-Magaña M, Li J, Beyer S, Johansson MC, Månsson AS, Edvardsson C, Durmo F, Gustafsson E, Boukredine A, Jeannot P, Schmidt K, Gezelius E, Menard JA, Garza R, Jakobsson J, de Neergaard T, Sundgren PC, Tiihonen AM, Haapasalo H, Rautajoki KJ, Nordenfelt P, Darabi A, Forsberg-Nilsson K, Pietras A, Talbot H, Bengzon J, Belting M. Governa V, et al. Among authors: menard ja. Sci Transl Med. 2024 Oct 30;16(771):eadk1168. doi: 10.1126/scitranslmed.adk1168. Epub 2024 Oct 30. Sci Transl Med. 2024. PMID: 39475570
Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration.
Offer S, Menard JA, Pérez JE, de Oliveira KG, Indira Chandran V, Johansson MC, Bång-Rudenstam A, Siesjö P, Ebbesson A, Hedenfalk I, Sundgren PC, Darabi A, Belting M. Offer S, et al. Among authors: menard ja. J Exp Clin Cancer Res. 2019 Jun 7;38(1):241. doi: 10.1186/s13046-019-1228-6. J Exp Clin Cancer Res. 2019. PMID: 31174567 Free PMC article.