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Caspases and their substrates.
Julien O, Wells JA. Julien O, et al. Cell Death Differ. 2017 Aug;24(8):1380-1389. doi: 10.1038/cdd.2017.44. Epub 2017 May 12. Cell Death Differ. 2017. PMID: 28498362 Free PMC article. Review.
Unraveling the mechanism of cell death induced by chemical fibrils.
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Julien O, et al. Among authors: o donoghue aj. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2001-10. doi: 10.1073/pnas.1524900113. Epub 2016 Mar 22. Proc Natl Acad Sci U S A. 2016. PMID: 27006500 Free PMC article.
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA. Seaman JE, et al. Among authors: julien o. Cell Death Differ. 2016 Oct;23(10):1717-26. doi: 10.1038/cdd.2016.62. Epub 2016 Jul 1. Cell Death Differ. 2016. PMID: 27367566 Free PMC article.
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.
Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. Calvo SE, et al. Among authors: julien o. Mol Cell Proteomics. 2017 Apr;16(4):512-523. doi: 10.1074/mcp.M116.063818. Epub 2017 Jan 25. Mol Cell Proteomics. 2017. PMID: 28122942 Free PMC article.
The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. Hill ME, et al. Among authors: julien o. ACS Chem Biol. 2018 Sep 21;13(9):2398-2405. doi: 10.1021/acschembio.8b00508. Epub 2018 Aug 14. ACS Chem Biol. 2018. PMID: 30080377
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE. Srinivasan SR, et al. Among authors: julien o. Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28. Mol Cancer Res. 2018. PMID: 28970360 Free PMC article.
Turning on caspases with genetics and small molecules.
Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Morgan CW, et al. Among authors: julien o. Methods Enzymol. 2014;544:179-213. doi: 10.1016/B978-0-12-417158-9.00008-X. Methods Enzymol. 2014. PMID: 24974291 Free PMC article. Review.
The DegraBase: a database of proteolysis in healthy and apoptotic human cells.
Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. Crawford ED, et al. Among authors: julien o. Mol Cell Proteomics. 2013 Mar;12(3):813-24. doi: 10.1074/mcp.O112.024372. Epub 2012 Dec 20. Mol Cell Proteomics. 2013. PMID: 23264352 Free PMC article.
Global cellular response to chemotherapy-induced apoptosis.
Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Wiita AP, et al. Among authors: julien o. Elife. 2013 Oct 29;2:e01236. doi: 10.7554/eLife.01236. Elife. 2013. PMID: 24171104 Free PMC article.
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