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Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.
Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A, Schrappe M, Postila V, Riikonen P, Pelkonen J, Niemeyer CM, Reth M. Jumaa H, et al. Nature. 2003 May 22;423(6938):452-6. doi: 10.1038/nature01608. Nature. 2003. PMID: 12761551
LAT links the pre-BCR to calcium signaling.
Su YW, Jumaa H. Su YW, et al. Immunity. 2003 Aug;19(2):295-305. doi: 10.1016/s1074-7613(03)00202-4. Immunity. 2003. PMID: 12932362
B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling.
Gerlach J, Ghosh S, Jumaa H, Reth M, Wienands J, Chan AC, Nitschke L. Gerlach J, et al. Eur J Immunol. 2003 Dec;33(12):3418-26. doi: 10.1002/eji.200324290. Eur J Immunol. 2003. PMID: 14635051
Identification of a pre-BCR lacking surrogate light chain.
Su YW, Flemming A, Wossning T, Hobeika E, Reth M, Jumaa H. Su YW, et al. J Exp Med. 2003 Dec 1;198(11):1699-706. doi: 10.1084/jem.20031428. Epub 2003 Nov 24. J Exp Med. 2003. PMID: 14638847 Free PMC article.
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