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Tumor necrosis factor alpha (TNF alpha) is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric oxide-(NO)-synthase (iNOS) or triggering serious cytotoxicity.
Müller-Werdan U, Schumann H, Fuchs R, Reithmann C, Loppnow H, Koch S, Zimny-Arndt U, He C, Darmer D, Jungblut P, Stadler J, Holtz J, Werdan K. Müller-Werdan U, et al. J Mol Cell Cardiol. 1997 Nov;29(11):2915-23. doi: 10.1006/jmcc.1997.0526. J Mol Cell Cardiol. 1997. PMID: 9405166
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