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2003 1
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Low concentration Tetrabromobisphenol A (TBBPA) elevating overall metabolism by inducing activation of the Ras signaling pathway.
Lu L, Hu J, Li G, An T. Lu L, et al. Among authors: hu j. J Hazard Mater. 2021 Aug 15;416:125797. doi: 10.1016/j.jhazmat.2021.125797. Epub 2021 Apr 1. J Hazard Mater. 2021. PMID: 33878653
Furthermore, long-term TBBPA exposure can double the levels of reactive oxygen species (ROS) released from mitochondria, thereby increasing Adenosine Monophosphate activated Protein kinase (AMPK) gene expression level to promote cellular proliferation. ...
Furthermore, long-term TBBPA exposure can double the levels of reactive oxygen species (ROS) released from mitochondria, thereby increasing …
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Méndez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, Wang J, Xie C, Driscoll PC, Tschaharganeh DF, Calvisi DF, Yuneva M, Chen X. Méndez-Lucas A, et al. Among authors: hu j. Cancer Res. 2017 Aug 15;77(16):4355-4364. doi: 10.1158/0008-5472.CAN-17-0498. Epub 2017 Jun 19. Cancer Res. 2017. PMID: 28630053 Free PMC article.
Different pyruvate kinase isoforms are expressed in a tissue-specific manner, with pyruvate kinase M2 (PKM2) suggested to be the predominant isoform in proliferating cells and cancer cells. ...Here we report that increased glucose catabolism through glycolysis and i …
Different pyruvate kinase isoforms are expressed in a tissue-specific manner, with pyruvate kinase M2 (PKM2) suggested to be t …
Linc-SCRG1 accelerates progression of hepatocellular carcinoma as a ceRNA of miR26a to derepress SKP2.
Hu JJ, Zhou C, Luo X, Luo SZ, Li ZH, Xu ZX, Xu MY. Hu JJ, et al. J Exp Clin Cancer Res. 2021 Jan 9;40(1):26. doi: 10.1186/s13046-020-01825-2. J Exp Clin Cancer Res. 2021. PMID: 33422101 Free PMC article.
RESULTS: LincSCRG1 was found to be strongly elevated in human HCC tissues and cell lines. MiR26a and S phase kinase-related protein 2 (SKP2) were predicted as the target miRNA for lincSCRG1 and the target gene for miR26a with direct binding sites, respectively. ...
RESULTS: LincSCRG1 was found to be strongly elevated in human HCC tissues and cell lines. MiR26a and S phase kinase-related protein 2 …
Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation.
Mo Y, Wu Y, Li X, Rao H, Tian X, Wu D, Qiu Z, Zheng G, Hu J. Mo Y, et al. Among authors: hu j. Eur J Pharmacol. 2020 Jan 15;867:172788. doi: 10.1016/j.ejphar.2019.172788. Epub 2019 Nov 8. Eur J Pharmacol. 2020. PMID: 31712058
Further evidence at the molecular level suggested that osthole reduced the expression of phosphor-extracellular signal-regulated kinase 1/2 (ERK1/2), proliferating cell nuclear antigen (PCNA) and Ki67 in livers of the AKT/c-Met mice. ...
Further evidence at the molecular level suggested that osthole reduced the expression of phosphor-extracellular signal-regulated kinase …
Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.
Xu Z, Hu J, Cao H, Pilo MG, Cigliano A, Shao Z, Xu M, Ribback S, Dombrowski F, Calvisi DF, Chen X. Xu Z, et al. Among authors: hu j. Exp Mol Med. 2018 Jan 5;50(1):e417. doi: 10.1038/emm.2017.158. Exp Mol Med. 2018. PMID: 29303510 Free PMC article.
Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 and mTORC2. ...
Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase a …
55 results