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Influence of tumour micro-environment heterogeneity on therapeutic response.
Junttila MR, de Sauvage FJ. Junttila MR, et al. Nature. 2013 Sep 19;501(7467):346-54. doi: 10.1038/nature12626. Nature. 2013. PMID: 24048067 Review.
Distinct thresholds govern Myc's biological output in vivo.
Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA, Brown-Swigart L, Johnson L, Evan GI. Murphy DJ, et al. Among authors: junttila mr. Cancer Cell. 2008 Dec 9;14(6):447-57. doi: 10.1016/j.ccr.2008.10.018. Cancer Cell. 2008. PMID: 19061836 Free PMC article.
p53--a Jack of all trades but master of none.
Junttila MR, Evan GI. Junttila MR, et al. Nat Rev Cancer. 2009 Nov;9(11):821-9. doi: 10.1038/nrc2728. Epub 2009 Sep 24. Nat Rev Cancer. 2009. PMID: 19776747 Review.
Selective activation of p53-mediated tumour suppression in high-grade tumours.
Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, Brown Swigart L, Pham DM, Seo Y, Evan GI, Martins CP. Junttila MR, et al. Nature. 2010 Nov 25;468(7323):567-71. doi: 10.1038/nature09526. Nature. 2010. PMID: 21107427 Free PMC article.
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.
Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I. Lo B, et al. Among authors: junttila m. J Cell Biol. 2012 Dec 24;199(7):1117-30. doi: 10.1083/jcb.201208080. J Cell Biol. 2012. PMID: 23266956 Free PMC article.
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.
Phan VT, Wu X, Cheng JH, Sheng RX, Chung AS, Zhuang G, Tran C, Song Q, Kowanetz M, Sambrone A, Tan M, Meng YG, Jackson EL, Peale FV, Junttila MR, Ferrara N. Phan VT, et al. Among authors: junttila mr. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6079-84. doi: 10.1073/pnas.1303302110. Epub 2013 Mar 25. Proc Natl Acad Sci U S A. 2013. PMID: 23530240 Free PMC article.
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.
Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA. Croci DO, et al. Among authors: junttila mr. Cell. 2014 Feb 13;156(4):744-58. doi: 10.1016/j.cell.2014.01.043. Cell. 2014. PMID: 24529377
Lymph node-independent liver metastasis in a model of metastatic colorectal cancer.
Enquist IB, Good Z, Jubb AM, Fuh G, Wang X, Junttila MR, Jackson EL, Leong KG. Enquist IB, et al. Among authors: junttila mr. Nat Commun. 2014 Mar 26;5:3530. doi: 10.1038/ncomms4530. Nat Commun. 2014. PMID: 24667486
An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, Junttila M, Stephan JP, Liu J, Pau G, Fearon ER, Jiang Z, Firestein R. Adler AS, et al. Among authors: junttila m. Genes Dev. 2014 May 15;28(10):1068-84. doi: 10.1101/gad.237206.113. Epub 2014 May 1. Genes Dev. 2014. PMID: 24788092 Free PMC article.
Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells.
Junttila TT, Li J, Johnston J, Hristopoulos M, Clark R, Ellerman D, Wang BE, Li Y, Mathieu M, Li G, Young J, Luis E, Lewis Phillips G, Stefanich E, Spiess C, Polson A, Irving B, Scheer JM, Junttila MR, Dennis MS, Kelley R, Totpal K, Ebens A. Junttila TT, et al. Among authors: junttila mr. Cancer Res. 2014 Oct 1;74(19):5561-71. doi: 10.1158/0008-5472.CAN-13-3622-T. Epub 2014 Sep 16. Cancer Res. 2014. PMID: 25228655
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