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Development of insulin resistance in mice lacking PGC-1α in adipose tissues.
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Kleiner S, et al. Among authors: jurczak mj. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9635-40. doi: 10.1073/pnas.1207287109. Epub 2012 May 29. Proc Natl Acad Sci U S A. 2012. PMID: 22645355 Free PMC article.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM. Banks AS, et al. Among authors: jurczak mj. Nature. 2015 Jan 15;517(7534):391-5. doi: 10.1038/nature13887. Epub 2014 Nov 17. Nature. 2015. PMID: 25409143 Free PMC article.
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. Jornayvaz FR, et al. Among authors: jurczak mj. Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E808-15. doi: 10.1152/ajpendo.00361.2010. Epub 2010 Aug 31. Am J Physiol Endocrinol Metab. 2010. PMID: 20807839 Free PMC article.
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: jurczak mj. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. Dominy JE Jr, et al. Among authors: jurczak mj. Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142079 Free PMC article.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI. Cantley JL, et al. Among authors: jurczak mj. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302688 Free PMC article.
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Galbo T, et al. Among authors: jurczak mj. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840067 Free PMC article.
126 results