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Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR. Liu X, et al. J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16. J Allergy Clin Immunol. 2017. PMID: 28216434
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. Bittner ZA, et al. Among authors: kummerle deschner jb. J Exp Med. 2021 Nov 1;218(11):e20201656. doi: 10.1084/jem.20201656. Epub 2021 Sep 23. J Exp Med. 2021. PMID: 34554188 Free PMC article.
Localization and functionality of the inflammasome in neutrophils.
Bakele M, Joos M, Burdi S, Allgaier N, Pöschel S, Fehrenbacher B, Schaller M, Marcos V, Kümmerle-Deschner J, Rieber N, Borregaard N, Yazdi A, Hector A, Hartl D. Bakele M, et al. J Biol Chem. 2014 Feb 21;289(8):5320-9. doi: 10.1074/jbc.M113.505636. Epub 2014 Jan 7. J Biol Chem. 2014. PMID: 24398679 Free PMC article.
Risk factors for severe Muckle-Wells syndrome.
Kümmerle-Deschner JB, Tyrrell PN, Reess F, Kötter I, Lohse P, Girschick H, Huemer C, Horneff G, Haas JP, Koitschev A, Deuter C, Benseler SM. Kümmerle-Deschner JB, et al. Arthritis Rheum. 2010 Dec;62(12):3783-91. doi: 10.1002/art.27696. Arthritis Rheum. 2010. PMID: 20722029 Free article.
[Genetics of cryopyrin-associated periodic syndrome].
Kümmerle-Deschner JB, Lohse P. Kümmerle-Deschner JB, et al. Z Rheumatol. 2017 May;76(4):313-321. doi: 10.1007/s00393-017-0271-y. Z Rheumatol. 2017. PMID: 28197772 Review. German.
[Cryopyrin-associated periodic syndrome].
Kümmerle-Deschner JB. Kümmerle-Deschner JB. Z Rheumatol. 2012 Apr;71(3):199-208. doi: 10.1007/s00393-011-0856-9. Z Rheumatol. 2012. PMID: 22527214 German.
[Periodic fever syndrome/autoinflammatory syndrome].
Kötter I, Schedel J, Kümmerle-Deschner JB. Kötter I, et al. Z Rheumatol. 2009 Mar;68(2):137-48; quiz 149. doi: 10.1007/s00393-009-0449-z. Z Rheumatol. 2009. PMID: 19255765 Review. German.
[Childhood vasculitis].
Kümmerle-Deschner JB, Thomas J, Benseler SM. Kümmerle-Deschner JB, et al. Z Rheumatol. 2015 Dec;74(10):863-6, 868-72, 874-7. doi: 10.1007/s00393-015-0014-x. Z Rheumatol. 2015. PMID: 26597725 Review. German.
39 results