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Page 1
Switching from concomitant therapy to tafluprost/timolol fixed combination.
Inoue K, Kawashima T, Katakura S, Shidara K, Fujimoto T, Kohmoto H, Shiokawa M, Moriyama R, Okayama R. Inoue K, et al. Among authors: kohmoto h. Clin Ophthalmol. 2018 Mar 21;12:549-554. doi: 10.2147/OPTH.S150595. eCollection 2018. Clin Ophthalmol. 2018. PMID: 29606852 Free PMC article.
Association between oxidative stress and microRNA expression pattern of ALS patients in the high-incidence area of the Kii Peninsula.
Arakawa Y, Itoh S, Fukazawa Y, Ishiguchi H, Kohmoto J, Hironishi M, Ito H, Kihira T. Arakawa Y, et al. Among authors: kohmoto j. Brain Res. 2020 Nov 1;1746:147035. doi: 10.1016/j.brainres.2020.147035. Epub 2020 Jul 30. Brain Res. 2020. PMID: 32739158
The aim of this study is to explore specific miRNAs in K-ALS and evaluate relationships between oxidative stress. We comprehensively analyzed serum miRNAs and examined urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), serum Cu/Zn superoxide dismutase (SOD) and serum Ne-hexanoy …
The aim of this study is to explore specific miRNAs in K-ALS and evaluate relationships between oxidative stress. We comprehensively …
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics.
Tucholski T, Cai W, Gregorich ZR, Bayne EF, Mitchell SD, McIlwain SJ, de Lange WJ, Wrobbel M, Karp H, Hite Z, Vikhorev PG, Marston SB, Lal S, Li A, Dos Remedios C, Kohmoto T, Hermsen J, Ralphe JC, Kamp TJ, Moss RL, Ge Y. Tucholski T, et al. Among authors: kohmoto t. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24691-24700. doi: 10.1073/pnas.2006764117. Epub 2020 Sep 23. Proc Natl Acad Sci U S A. 2020. PMID: 32968017 Free PMC article.
Neutron activation analysis of scalp hair from ALS patients and residents in the Kii Peninsula, Japan.
Kihira T, Sakurai I, Yoshida S, Wakayama I, Takamiya K, Okumura R, Iinuma Y, Iwai K, Kajimoto Y, Hiwatani Y, Kohmoto J, Okamoto K, Kokubo Y, Kuzuhara S. Kihira T, et al. Among authors: kohmoto j. Biol Trace Elem Res. 2015 Mar;164(1):36-42. doi: 10.1007/s12011-014-0202-6. Epub 2014 Dec 20. Biol Trace Elem Res. 2015. PMID: 25524522
The aim of this study was to evaluate the accumulation of transition metals in the scalp hair of amyotrophic lateral sclerosis (ALS) patients in the Koza/Kozagawa/Kushimoto (K) area (K-ALS) in the Kii Peninsula, Japan. Metal contents were measured in the unpermed, u …
The aim of this study was to evaluate the accumulation of transition metals in the scalp hair of amyotrophic lateral sclerosis (ALS) patient …
Cellular mechanisms for synthesis and secretion of atrial natriuretic peptide and brain natriuretic peptide in cultured rat atrial cells.
Suzuki E, Hirata Y, Kohmoto O, Sugimoto T, Hayakawa H, Matsuoka H, Sugimoto T, Kojima M, Kangawa K, Minamino N, et al. Suzuki E, et al. Among authors: kohmoto o. Circ Res. 1992 Nov;71(5):1039-48. doi: 10.1161/01.res.71.5.1039. Circ Res. 1992. PMID: 1394868

Endothelin (10(-7) M, +61%), 12-O-tetradecanoylphorbol 13-acetate (TPA, 10(-6) M, +62%), the calcium ionophore A23187 (10(-6) M, +95%), and Bay K 8644 (10(-6) M, +34%) (p < 0.05 each) all increased the secretion of ANP into the culture media in a dose-dependent fashion.

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Endothelin (10(-7) M, +61%), 12-O-tetradecanoylphorbol 13-acetate (TPA, 10(-6) M, +62%), the calcium ionophore A23187 (10(-6) M, +95%), and …
UCN Production With a Single Crystal of Ortho-Deuterium.
Utsuro M, Tanaka M, Mishima K, Nagai Y, Shima T, Fukuda Y, Kohmoto T, Momose T, Moriai A, Okumura K, Yoshino H. Utsuro M, et al. Among authors: kohmoto t. J Res Natl Inst Stand Technol. 2005 Jun 1;110(3):273-7. doi: 10.6028/jres.110.038. Print 2005 May-Jun. J Res Natl Inst Stand Technol. 2005. PMID: 27308135 Free PMC article.
The present paper reports on the preliminary experimental results concerning a new concept of ultracold neutron production with a single crystal converter of ortho-deuterium lying in the ground rotational state at the low temperature of about 10 K, which should make it pos …
The present paper reports on the preliminary experimental results concerning a new concept of ultracold neutron production with a single cry …
[Changes in the incidence and clinical features of ALS in the Koza, Kozagawa, and Kushimoto area of the Kii Peninsula--from the 1960s to the 2000s (follow-up study)].
Kihira T, Yoshida S, Murata K, Ishiguti H, Kondo T, Kohmoto J, Okamoto K, Kokubo Y, Kuzuhara S. Kihira T, et al. Among authors: kohmoto j. Brain Nerve. 2010 Jan;62(1):72-80. Brain Nerve. 2010. PMID: 20112794 Japanese.
Probable and definite ALS patients diagnosed by neurologists using the El Escorial criteria in K area during the research periods were collected. The crude incidence rate of ALS in K area were similar in period I, i.e. 6.0/100,000, and in period III, i.e., 5.7/100,0 …
Probable and definite ALS patients diagnosed by neurologists using the El Escorial criteria in K area during the research periods wer …
Controlling the Adsorption of Ruthenium Complexes on Carbon Surfaces through Noncovalent Bonding with Pyrene Anchors: An Electrochemical Study.
Kohmoto M, Ozawa H, Yang L, Hagio T, Matsunaga M, Haga MA. Kohmoto M, et al. Langmuir. 2016 May 3;32(17):4141-52. doi: 10.1021/acs.langmuir.6b00405. Epub 2016 Apr 20. Langmuir. 2016. PMID: 27065057
The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 10(-5) s(-1)) < Ru-2 with four pyrenes (4.1 10(-5) s(-1)) < Ru-3 with two pyrenes (6.8 10(-5) s(-1)) Ru-4 with one pyrene (4.1 10(-3) s(-1)). ...

The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 10(-5) s(-1)) < Ru-2 with fo

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Alterations in cation homeostasis in cultured chick ventricular cells during and after recovery from adenosine triphosphate depletion.
Ishida H, Kohmoto O, Bridge JH, Barry WH. Ishida H, et al. Among authors: kohmoto o. J Clin Invest. 1988 Apr;81(4):1173-81. doi: 10.1172/JCI113432. J Clin Invest. 1988. PMID: 3350967 Free PMC article.
These abnormalities in K homeostasis were associated with a decrease in cell volume and water content per milligram of protein. ...However, metabolic inhibition of ATP production produces persistent abnormalities in K homeostasis, associated with functional abnormal …
These abnormalities in K homeostasis were associated with a decrease in cell volume and water content per milligram of protein. ...Ho …
Activation of furosemide-sensitive K+ fluxes in myocytes by ouabain and recovery from metabolic inhibition.
Kohmoto O, Krueger JA, Barry WH. Kohmoto O, et al. Am J Physiol. 1990 Sep;259(3 Pt 2):H962-72. doi: 10.1152/ajpheart.1990.259.3.H962. Am J Physiol. 1990. PMID: 2396700
Modulation of transsarcolemmal K+ flux mediated by the furosemide-sensitive K(+)-Cl- (or Na(+)-K(+)-Cl-) cotransport carrier was studied in cultured chick embryo ventricular cells. ...With respect to K+ influx, there were 1) a ouabain-sensitive K …
Modulation of transsarcolemmal K+ flux mediated by the furosemide-sensitive K(+)-Cl- (or Na(+)-K(+)-Cl-) cotransport ca …