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miRNAs in osteoclast biology.
Weivoda MM, Lee SK, Monroe DG. Weivoda MM, et al. Bone. 2021 Feb;143:115757. doi: 10.1016/j.bone.2020.115757. Epub 2020 Nov 17. Bone. 2021. PMID: 33212320 Free PMC article. Review.
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism.
Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S. Weivoda MM, et al. Nat Commun. 2020 Jan 7;11(1):87. doi: 10.1038/s41467-019-14003-6. Nat Commun. 2020. PMID: 31911667 Free PMC article. Clinical Trial.
Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice.
Farr JN, Weivoda MM, Nicks KM, Fraser DG, Negley BA, Onken JL, Thicke BS, Ruan M, Liu H, Forrest D, Hawse JR, Khosla S, Monroe DG. Farr JN, et al. J Bone Miner Res. 2018 Apr;33(4):720-731. doi: 10.1002/jbmr.3351. Epub 2017 Dec 27. J Bone Miner Res. 2018. PMID: 29206307 Free PMC article.
Targeting cellular senescence prevents age-related bone loss in mice.
Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Farr JN, et al. Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Nat Med. 2017. PMID: 28825716 Free PMC article.