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Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.
Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE 3rd, Klein E, Kirschner DE, Morris SM Jr, Lin PL, Flynn JL. Mattila JT, et al. J Immunol. 2013 Jul 15;191(2):773-84. doi: 10.4049/jimmunol.1300113. Epub 2013 Jun 7. J Immunol. 2013. PMID: 23749634 Free PMC article.
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, Flynn JL, Barry CE 3rd. Via LE, et al. Infect Immun. 2008 Jun;76(6):2333-40. doi: 10.1128/IAI.01515-07. Epub 2008 Mar 17. Infect Immun. 2008. PMID: 18347040 Free PMC article.