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A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.
Elife. 2018 Feb 21;7:e32766. doi: 10.7554/eLife.32766.
Elife. 2018.
PMID: 29465396
Free PMC article.
A water-mediated allosteric network governs activation of Aurora kinase A.
Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM.
Cyphers S, et al.
Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6.
Nat Chem Biol. 2017.
PMID: 28166210
Free PMC article.
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A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.
Levinson NM, Boxer SG.
Levinson NM, et al.
Nat Chem Biol. 2014 Feb;10(2):127-32. doi: 10.1038/nchembio.1404. Epub 2013 Dec 1.
Nat Chem Biol. 2014.
PMID: 24292070
Free PMC article.
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