Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 2
2001 1
2002 1
2005 1
2006 1
2007 1
2008 1
2012 1
2013 2
2014 1
2016 1
2017 2
2018 1
2019 1
2021 1
2022 2
2023 4
2024 4
2025 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

25 results

Results by year

Filters applied: . Clear all
Page 1
Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.
Zhang ZX, Tian Y, Li S, Jing HB, Cai J, Li M, Xing GG. Zhang ZX, et al. Cell Commun Signal. 2024 Aug 27;22(1):416. doi: 10.1186/s12964-024-01797-2. Cell Commun Signal. 2024. PMID: 39192337 Free PMC article.
Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. ...Also, HDAC2 requires the formation of a corepressor complex with MeCP2 and Sin3A to execute transcriptional regulation …
Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanism …
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.
Iglesia MD, Jayasinghe RG, Chen S, Terekhanova NV, Herndon JM, Storrs E, Karpova A, Zhou DC, Naser Al Deen N, Shinkle AT, Lu RJ, Caravan W, Houston A, Zhao Y, Sato K, Lal P, Street C, Martins Rodrigues F, Southard-Smith AN, Targino da Costa ALN, Zhu H, Mo CK, Crowson L, Fulton RS, Wyczalkowski MA, Fronick CC, Fulton LA, Sun H, Davies SR, Appelbaum EL, Chasnoff SE, Carmody M, Brooks C, Liu R, Wendl MC, Oh C, Bender D, Cruchaga C, Harari O, Bredemeyer A, Lavine K, Bose R, Margenthaler J, Held JM, Achilefu S, Ademuyiwa F, Aft R, Ma C, Colditz GA, Ju T, Oh ST, Fitzpatrick J, Hwang ES, Shoghi KI, Chheda MG, Veis DJ, Chen F, Fields RC, Gillanders WE, Ding L. Iglesia MD, et al. Nat Cancer. 2024 Nov;5(11):1713-1736. doi: 10.1038/s43018-024-00773-6. Epub 2024 Oct 30. Nat Cancer. 2024. PMID: 39478117 Free PMC article.
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. ...Furthermore, we identify key genes defining the basal-like (SOX6 a …
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that charac …
Ligand activation mechanisms of human KCNQ2 channel.
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J. Ma D, et al. Nat Commun. 2023 Oct 19;14(1):6632. doi: 10.1038/s41467-023-42416-x. Nat Commun. 2023. PMID: 37857637 Free PMC article.
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. ...
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential …
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.
Iglesia MD, Jayasinghe RG, Chen S, Terekhanova NV, Herndon JM, Storrs E, Karpova A, Zhou DC, Al Deen NN, Shinkle AT, Lu RJ, Caravan W, Houston A, Zhao Y, Sato K, Lal P, Street C, Rodrigues FM, Southard-Smith AN, Targino da Costa ALN, Zhu H, Mo CK, Crowson L, Fulton RS, Wyczalkowski MA, Fronick CC, Fulton LA, Sun H, Davies SR, Appelbaum EL, Chasnoff SE, Carmody M, Brooks C, Liu R, Wendl MC, Oh C, Bender D, Cruchaga C, Harari O, Bredemeyer A, Lavine K, Bose R, Margenthaler J, Held JM, Achilefu S, Ademuyiwa F, Aft R, Ma C, Colditz GA, Ju T, Oh ST, Fitzpatrick J, Hwang ES, Shoghi KI, Chheda MG, Veis DJ, Chen F, Fields RC, Gillanders WE, Ding L. Iglesia MD, et al. bioRxiv [Preprint]. 2023 Nov 2:2023.10.31.565031. doi: 10.1101/2023.10.31.565031. bioRxiv. 2023. Update in: Nat Cancer. 2024 Nov;5(11):1713-1736. doi: 10.1038/s43018-024-00773-6. PMID: 37961519 Free PMC article. Updated. Preprint.
Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast cancer subtypes have different cells of origin within that lineage. ...Furthermore, we identify key genes defining the basal-like ( PRKCA , SOX6 , RGS6 , KCNQ3 ) and …
Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast cancer subtypes have different c …
KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas.
Shorthouse D, Zhuang L, Rahrmann EP, Kosmidou C, Wickham Rahrmann K, Hall M, Greenwood BM, Devonshire G, Gilbertson RJ, Fitzgerald RC, Hall BA. Shorthouse D, et al. Life Sci Alliance. 2023 Sep 25;6(12):e202302124. doi: 10.26508/lsa.202302124. Print 2023 Dec. Life Sci Alliance. 2023. PMID: 37748809 Free PMC article.
KCNQ1 and KCNQ3 mediate the WNT pathway and MYC to increase proliferation through resultant effects on cadherin junctions. This also highlights novel roles of KCNQ3 in non-excitable tissues. We also discover that activity of KCNQ3 sensitises cancer cel …
KCNQ1 and KCNQ3 mediate the WNT pathway and MYC to increase proliferation through resultant effects on cadherin junctions. This also …
Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.
Yang Z, Zheng Y, Ma D, Wang L, Zhang J, Song T, Wang Y, Zhang Y, Nan F, Su N, Gao Z, Guo J. Yang Z, et al. Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2416738122. doi: 10.1073/pnas.2416738122. Epub 2025 Apr 2. Proc Natl Acad Sci U S A. 2025. PMID: 40172963
The human voltage-gated potassium channels KCNQ2, KCNQ3, and KCNQ5 can form homo- and heterotetrameric channels that are responsible for generating the neuronal M current and maintaining the membrane potential stable. ...
The human voltage-gated potassium channels KCNQ2, KCNQ3, and KCNQ5 can form homo- and heterotetrameric channels that are responsible …
SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinoma.
Foley K, Shorthouse D, Rahrmann E, Zhuang L, Devonshire G, Gilbertson RJ; OCCAMS consortium; Fitzgerald RC, Hall BA. Foley K, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166867. doi: 10.1016/j.bbadis.2023.166867. Epub 2023 Aug 28. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37648039 Free article.
In this work we present an analysis of lymph node metastases found by radiological and pathological sampling, identifying new roles of the genes SMAD4 and KCNQ3 in metastasis. Through transcriptomic analysis we find that both genes are associated with canonical Wnt pathway …
In this work we present an analysis of lymph node metastases found by radiological and pathological sampling, identifying new roles of the g …
A Potential Prognostic Gene Signature Associated with p53-Dependent NTRK1 Activation and Increased Survival of Neuroblastoma Patients.
Currie D, Wong N, Zane I, Rix T, Vardakastanis M, Claxton A, Ong KKV, Macmorland W, Poivet A, Brooks A, Niola P, Huntley D, Montano X. Currie D, et al. Cancers (Basel). 2024 Feb 8;16(4):722. doi: 10.3390/cancers16040722. Cancers (Basel). 2024. PMID: 38398114 Free PMC article.
Neuroblastoma is the most common extracranial solid tumour in children, comprising close to 10% of childhood cancer-related deaths. We have demonstrated that activation of NTRK1 by TP53 repression of PTPN6 expression is significantly associated with favourable survival in …
Neuroblastoma is the most common extracranial solid tumour in children, comprising close to 10% of childhood cancer-related deaths. W …
Tamoxifen inhibition of kv7.2/kv7.3 channels.
Ferrer T, Aréchiga-Figueroa IA, Shapiro MS, Tristani-Firouzi M, Sanchez-Chapula JA. Ferrer T, et al. PLoS One. 2013 Sep 24;8(9):e76085. doi: 10.1371/journal.pone.0076085. eCollection 2013. PLoS One. 2013. PMID: 24086693 Free PMC article.
In this study, we demonstrate that tamoxifen, an estrogen receptor antagonist used in the treatment of breast cancer, inhibits Kv7.2/Kv7.3 currents heterologously expressed in human embryonic kidney HEK-293 cells. ...
In this study, we demonstrate that tamoxifen, an estrogen receptor antagonist used in the treatment of breast cancer, inhibits Kv7.2/ …
Identification of gene co-expression modules and hub genes associated with lymph node metastasis of papillary thyroid cancer.
Zhai T, Muhanhali D, Jia X, Wu Z, Cai Z, Ling Y. Zhai T, et al. Endocrine. 2019 Dec;66(3):573-584. doi: 10.1007/s12020-019-02021-9. Epub 2019 Jul 22. Endocrine. 2019. PMID: 31332712
Papillary thyroid cancer (PTC) is the most prevalent histological type among thyroid cancers, and some patients are at a high risk for recurrent disease or even death. ...Relapse-free survival analyses found that 11 genes (KCNQ3, MET, FN1, ITGA3, RUNX1, ITGA2 …
Papillary thyroid cancer (PTC) is the most prevalent histological type among thyroid cancers, and some patients are at a high …
25 results