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488 results

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Page 1
KCa3.1 in diabetic kidney disease.
Huang C, Chen XM, Pollock CA. Huang C, et al. Curr Opin Nephrol Hypertens. 2022 Jan 1;31(1):129-134. doi: 10.1097/MNH.0000000000000751. Curr Opin Nephrol Hypertens. 2022. PMID: 34710887 Review.
Innovative strategies to prevent or limit the progression of DKD are urgently needed due to the limitation of existing treatments. KCa3.1, a potassium channel, is involved in a range of biological processes from cell survival to cell death. This review summarizes th …
Innovative strategies to prevent or limit the progression of DKD are urgently needed due to the limitation of existing treatments. KCa3
KCa3.1 Channels and Glioblastoma: In Vitro Studies.
Klumpp L, Sezgin EC, Skardelly M, Eckert F, Huber SM. Klumpp L, et al. Curr Neuropharmacol. 2018;16(5):627-635. doi: 10.2174/1570159X15666170808115821. Curr Neuropharmacol. 2018. PMID: 28786347 Free PMC article. Review.
Moreover, KCa3.1 channels have been shown to crucially contribute to resistance against radiotherapy. Futhermore, the original in vitro data on KCa3.1 channel expression in subtypes of glioblastoma stem(-like) cells propose KCa3.1 as mark …
Moreover, KCa3.1 channels have been shown to crucially contribute to resistance against radiotherapy. Futhermore, the original …
Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis.
Lin Y, Zhao YJ, Zhang HL, Hao WJ, Zhu RD, Wang Y, Hu W, Zhou RP. Lin Y, et al. Front Immunol. 2022 Oct 5;13:997621. doi: 10.3389/fimmu.2022.997621. eCollection 2022. Front Immunol. 2022. PMID: 36275686 Free PMC article. Review.
Earlier studies have demonstrated abnormal activation of KCa3.1 in the peripheral blood and articular synovium of RA patients. Moreover, knockout of KCa3.1 reduced the severity of synovial inflammation and cartilage damage to a significant extent in a …
Earlier studies have demonstrated abnormal activation of KCa3.1 in the peripheral blood and articular synovium of RA patients. …
Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis.
Zeng B, Huang Y, Chen S, Xu R, Xu L, Qiu J, Shi F, Liu S, Zha Q, Ouyang D, He X. Zeng B, et al. Cell Mol Immunol. 2022 Aug;19(8):925-943. doi: 10.1038/s41423-022-00891-0. Epub 2022 Jul 7. Cell Mol Immunol. 2022. PMID: 35799057 Free PMC article.
Mechanistically, DSS potentiated NLRP3 inflammasome activation in macrophages by augmenting KCa3.1-mediated potassium ion (K(+)) efflux. Furthermore, we found that pharmacologic blockade of the K(+) channel KCa3.1 with TRAM-34 or genetic depletion of t …
Mechanistically, DSS potentiated NLRP3 inflammasome activation in macrophages by augmenting KCa3.1-mediated potassium ion (K(+ …
Kca3.1-Related Cellular Signalling Involved in Cancer Proliferation.
Calderón Artavia CG, Arvelo Álvarez FA. Calderón Artavia CG, et al. Cell Physiol Biochem. 2024 Mar 16;58(2):107-127. doi: 10.33594/000000688. Cell Physiol Biochem. 2024. PMID: 38623063 Free article. Review.
In particular, the so-called intermediate conductance KCa3.1 (IKCa) is reported to play a significant role in uncontrolled cell cycle signaling, among other malignant processes driven by cancer hallmarks. ...This review is dedicated to the connection of KCa3. …
In particular, the so-called intermediate conductance KCa3.1 (IKCa) is reported to play a significant role in uncontrolled cel …
KCa3.1: a new player in progressive kidney disease.
Huang C, Pollock CA, Chen XM. Huang C, et al. Curr Opin Nephrol Hypertens. 2015 Jan;24(1):61-6. doi: 10.1097/MNH.0000000000000083. Curr Opin Nephrol Hypertens. 2015. PMID: 25415613 Review.
Recent findings demonstrate that genetic deletion or pharmacologic inhibition of KCa3.1 significantly reduces the development of diabetic nephropathy in animal models. However, the consequences of blockade of KCa3.1 in preventing and treating establish …
Recent findings demonstrate that genetic deletion or pharmacologic inhibition of KCa3.1 significantly reduces the development …
Role of KCa3.1 Channels in Modulating Ca(2+) Oscillations during Glioblastoma Cell Migration and Invasion.
Catacuzzeno L, Franciolini F. Catacuzzeno L, et al. Int J Mol Sci. 2018 Sep 29;19(10):2970. doi: 10.3390/ijms19102970. Int J Mol Sci. 2018. PMID: 30274242 Free PMC article. Review.
Notably, the elevated cytosolic [Ca(2+)](i) activates the intermediate conductance Ca(2+)-activated K (KCa3.1) channels highly expressed in the plasma membrane of GBM cells, and the resulting K+ efflux hyperpolarizes the cell membrane. ...In accordance, we recently …
Notably, the elevated cytosolic [Ca(2+)](i) activates the intermediate conductance Ca(2+)-activated K (KCa3.1) channels highly …
Role of KCa3.1 Channels in CNS Diseases: A Concise Review.
Sugunan S, Nampoothiri SS, Garg T, Krishnamurthy RG. Sugunan S, et al. CNS Neurol Disord Drug Targets. 2016;15(10):1299-1305. doi: 10.2174/1871527315666160822111913. CNS Neurol Disord Drug Targets. 2016. PMID: 27549144 Review.
KCa3.1 protein is part of a heterotetrameric voltage-independent potassium channel, the activity of which depends on the intracellular calcium binding to calmodulin. KCa3.1 is immensely significant in regulating immune responses and primarily expressed
KCa3.1 protein is part of a heterotetrameric voltage-independent potassium channel, the activity of which depends on the intra
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Huang C, Yi H, Shi Y, Cao Q, Shi Y, Cheng D, Braet F, Chen XM, Pollock CA. Huang C, et al. Front Cell Dev Biol. 2021 Feb 19;9:573814. doi: 10.3389/fcell.2021.573814. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33681190 Free PMC article.
We have previously shown that blockade of the calcium-activated potassium channel KCa3.1 ameliorates diabetic renal fibrosis. However, the mechanistic link between KCa3.1 and mitochondrial quality control in diabetic kidney disease is not yet known. .. …
We have previously shown that blockade of the calcium-activated potassium channel KCa3.1 ameliorates diabetic renal fibrosis. …
KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing.
Liu D, Chen H, Fu Y, Yao Y, He S, Wang Y, Cao Z, Wang X, Yang M, Zhao Q. Liu D, et al. Cardiovasc Ther. 2023 Mar 30;2023:3939360. doi: 10.1155/2023/3939360. eCollection 2023. Cardiovasc Ther. 2023. PMID: 37035755 Free PMC article.
CONCLUSIONS: KCa3.1 promotes proinflammatory exosome secretion through the AKT/Rab27a signaling pathway. Inhibiting the KCa3.1/AKT/Rab27a signaling pathway reduces myocardial tissue structural remodeling in AF....
CONCLUSIONS: KCa3.1 promotes proinflammatory exosome secretion through the AKT/Rab27a signaling pathway. Inhibiting the KCa
488 results