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CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.
Waarts MR, Mowla S, Boileau M, Martinez Benitez AR, Sango J, Bagish M, Fernández-Maestre I, Shan Y, Eisman SE, Park YC, Wereski M, Csete I, O'Connor K, Romero-Vega AC, Miles LA, Xiao W, Wu X, Koche RP, Armstrong SA, Shih AH, Papapetrou EP, Butler JM, Cai SF, Bowman RL, Levine RL. Waarts MR, et al. Cancer Discov. 2024 Oct 4;14(10):1860-1878. doi: 10.1158/2159-8290.CD-23-1092. Cancer Discov. 2024. PMID: 38819218 Free PMC article.
Our data reveal that loss of the histone demethylase family members Kdm3b and Jmjd1c specifically reduces the fitness of Idh2- and Tet2-mutant HSPCs. Kdm3b loss in mutant cells leads to decreased expression of critical cytokine receptors including Mpl, rendering mut …
Our data reveal that loss of the histone demethylase family members Kdm3b and Jmjd1c specifically reduces the fitness of Idh2- and Te …
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.
Kim YY, Gryder BE, Sinniah R, Peach ML, Shern JF, Abdelmaksoud A, Pomella S, Woldemichael GM, Stanton BZ, Milewski D, Barchi JJ Jr, Schneekloth JS Jr, Chari R, Kowalczyk JT, Shenoy SR, Evans JR, Song YK, Wang C, Wen X, Chou HC, Gangalapudi V, Esposito D, Jones J, Procter L, O'Neill M, Jenkins LM, Tarasova NI, Wei JS, McMahon JB, O'Keefe BR, Hawley RG, Khan J. Kim YY, et al. Nat Commun. 2024 Feb 24;15(1):1703. doi: 10.1038/s41467-024-45902-y. Nat Commun. 2024. PMID: 38402212 Free PMC article.
Enzymatic assays confirm the inhibition of multiple KDMs with the highest selectivity for KDM3B. Structural similarity search of P3FI-63 identifies P3FI-90 with improved solubility and potency. Biophysical binding of P3FI-90 to KDM3B is demonstrated using NMR and SP …
Enzymatic assays confirm the inhibition of multiple KDMs with the highest selectivity for KDM3B. Structural similarity search of P3FI …
Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications.
Yoo J, Kim GW, Jeon YH, Lee SW, Kwon SH. Yoo J, et al. Cell Death Dis. 2024 Jun 26;15(6):451. doi: 10.1038/s41419-024-06850-z. Cell Death Dis. 2024. PMID: 38926399 Free PMC article. Review.
However, despite a number of studies pointing out their importance in tumorigenesis, KDM3B and KDM3C are relatively overlooked. KDM3B and KDM3C show context-dependent functions, showing pro- or anti-tumorigenic abilities in different cancers. Thus, this review provi …
However, despite a number of studies pointing out their importance in tumorigenesis, KDM3B and KDM3C are relatively overlooked. KD …
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement.
Gray ZH, Chakraborty D, Duttweiler RR, Alekbaeva GD, Murphy SE, Chetal K, Ji F, Ferman BI, Honer MA, Wang Z, Myers C, Sun R, Kaniskan HÜ, Toma MM, Bondarenko EA, Santoro JN, Miranda C, Dillingham ME, Tang R, Gozani O, Jin J, Skorski T, Duy C, Lee H, Sadreyev RI, Whetstine JR. Gray ZH, et al. Cell. 2023 Oct 12;186(21):4528-4545.e18. doi: 10.1016/j.cell.2023.09.009. Epub 2023 Oct 2. Cell. 2023. PMID: 37788669 Free PMC article.
This balance is controlled by the crosstalk between lysine demethylase KDM3B and methyltransferase G9a/EHMT2. KDM3B depletion increases H3K9me1/2 levels and reduces CTCF occupancy at the MLL/KMT2A locus, in turn promoting amplification and rearrangements. ...Further …
This balance is controlled by the crosstalk between lysine demethylase KDM3B and methyltransferase G9a/EHMT2. KDM3B depletion …
Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice.
Kim YG, Bak MS, Kim A, Kim Y, Chae YC, Kim YL, Chun YS, An JY, Seo SB, Kim SJ, Lee YS. Kim YG, et al. Mol Brain. 2021 Jul 3;14(1):106. doi: 10.1186/s13041-021-00815-5. Mol Brain. 2021. PMID: 34217333 Free PMC article.
To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b(+/-)) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectivel …
To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b …
KDM3B-ETF1 fusion gene downregulates LMO2 via the WNT/beta-catenin signaling pathway, promoting metastasis of invasive ductal carcinoma.
Hu A, Hong F, Li D, Xie Q, Chen K, Zhu L, He H. Hu A, et al. Cancer Gene Ther. 2022 Feb;29(2):215-224. doi: 10.1038/s41417-021-00301-z. Epub 2021 Apr 7. Cancer Gene Ther. 2022. PMID: 33828234
In this study, we investigate the possible effects KDM3B-ETF1 fusion gene has on breast cancer cell metastasis, invasion and its downstream signaling mediators as revealed from RNA sequence data analysis. As predicted, KDM3B-ETF1 expression was increased in breast c …
In this study, we investigate the possible effects KDM3B-ETF1 fusion gene has on breast cancer cell metastasis, invasion and its down …
Two patients with KDM3B variants and new presentations of Diets-Jongmans syndrome.
Zhao X, Yu T, Tang J, Yao RE, Li N, Wang J. Zhao X, et al. Neurogenetics. 2023 Apr;24(2):95-101. doi: 10.1007/s10048-023-00711-1. Epub 2023 Feb 9. Neurogenetics. 2023. PMID: 36757469
KDM3B is located on chromosome 5q31 and encodes KDM3B, which is involved in histone demethylation and epigenetic regulation. ...KDM3B c.5070 + 1G > A is the first KDM3B splice-site variant and was identified as a germline variant. ...
KDM3B is located on chromosome 5q31 and encodes KDM3B, which is involved in histone demethylation and epigenetic regulation. . …
Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11.
Wang Y, Zhao Y, Wang H, Zhang C, Wang M, Yang Y, Xu X, Hu Z. Wang Y, et al. FEBS Open Bio. 2020 Apr;10(4):637-643. doi: 10.1002/2211-5463.12823. Epub 2020 Mar 18. FEBS Open Bio. 2020. PMID: 32107878 Free PMC article.
KDM3B overexpression in HT-1080 cells results in decreased histone H3 lysine 9 methylation. ...In summary, we identify here KDM3B as a potential epigenetic regulator of ferroptosis....
KDM3B overexpression in HT-1080 cells results in decreased histone H3 lysine 9 methylation. ...In summary, we identify here KDM3B …
KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARalpha.
Wang X, Fan H, Xu C, Jiang G, Wang H, Zhang J. Wang X, et al. Cancer Cell Int. 2019 Oct 4;19:256. doi: 10.1186/s12935-019-0979-7. eCollection 2019. Cancer Cell Int. 2019. PMID: 31592194 Free PMC article.
METHODS: First, we established a KDM3B knockdown NB4 cell model to determine the functional characteristics of KDM3B by cell proliferation assay and flow cytometry. ...Moreover, knocking down KDM3B inhibited the ATRA-induced degradation of the PML/RARalpha on …
METHODS: First, we established a KDM3B knockdown NB4 cell model to determine the functional characteristics of KDM3B by cell p …
Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells.
An MJ, Kim DH, Kim CH, Kim M, Rhee S, Seo SB, Kim JW. An MJ, et al. Biochem Biophys Res Commun. 2019 Jan 8;508(2):576-582. doi: 10.1016/j.bbrc.2018.11.179. Epub 2018 Dec 1. Biochem Biophys Res Commun. 2019. PMID: 30514438
Here we demonstrated the overexpression of KDM3B in liver tissue of HCC patients using public RNA-seq data. Ablation of KDM3B by CRISPR/Cas9 retarded the cell cycle and proliferation of hepatocarcinoma HepG2 cells. Approximately 30% of KDM3B knockout cells ex …
Here we demonstrated the overexpression of KDM3B in liver tissue of HCC patients using public RNA-seq data. Ablation of KDM3B …
78 results