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Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.
Sur I, Rozell B, Jaks V, Bergström A, Toftgård R. Sur I, et al. J Cell Sci. 2006 Sep 1;119(Pt 17):3593-601. doi: 10.1242/jcs.03070. Epub 2006 Aug 15. J Cell Sci. 2006. PMID: 16912082
Here, we show that overexpression of Klf5 in the basal layer of the epidermis during embryogenesis affects epidermal development and disrupts epithelial-mesenchymal interactions necessary for skin adnexae formation as well as craniofacial morphogenesis. ...Ou …
Here, we show that overexpression of Klf5 in the basal layer of the epidermis during embryogenesis affects epidermal de …
Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles.
Sur I, Undén AB, Toftgård R. Sur I, et al. Eur J Cell Biol. 2002 Jun;81(6):323-34. doi: 10.1078/0171-9335-00257. Eur J Cell Biol. 2002. PMID: 12113473
In this report we describe the identification of Kruppel-like factor 5 (KLF5/BTEB2) in a yeast one-hybrid screen using a keratinocyte-specific, NF-kappaB binding site as bait. ...The KLF5 mRNA and the protein is expressed in keratinocytes and throughou …
In this report we describe the identification of Kruppel-like factor 5 (KLF5/BTEB2) in a yeast one-hybrid screen using a keratinoc
Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells.
Yang Y, Goldstein BG, Nakagawa H, Katz JP. Yang Y, et al. FASEB J. 2007 Feb;21(2):543-50. doi: 10.1096/fj.06-6694com. Epub 2006 Dec 8. FASEB J. 2007. PMID: 17158781
Here, using mouse primary esophageal keratinocytes as a model, we identify a critical role for Klf5 in regulating squamous epithelial proliferation via the epidermal growth factor receptor (EGFR), which, like Klf5, is localized to basal cells in squamo …
Here, using mouse primary esophageal keratinocytes as a model, we identify a critical role for Klf5 in regulating squamous epi …
Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.
Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, Swamynathan SK. Kenchegowda D, et al. Dev Biol. 2011 Aug 1;356(1):5-18. doi: 10.1016/j.ydbio.2011.05.005. Epub 2011 May 11. Dev Biol. 2011. PMID: 21600198 Free PMC article.
Previously, we have demonstrated the role of Klf4 in the mouse ocular surface. Herein, we determined the role of the structurally related Klf5, using Klf5-conditional null (Klf5CN) mice derived by mating Klf5-LoxP and Le-Cre mice. ...Co-ablation of Klf4 and …
Previously, we have demonstrated the role of Klf4 in the mouse ocular surface. Herein, we determined the role of the structurally related …