Clonal distribution of multidrug-resistant Enterobacter cloacae

Diagn Microbiol Infect Dis. 2015 Apr;81(4):264-8. doi: 10.1016/j.diagmicrobio.2015.01.003. Epub 2015 Jan 16.

Abstract

A multilocus sequence typing (MLST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various β-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme.

Keywords: Enterobacter cloacae; MLST; Multidrug-resistant bacteria; Prevalence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Drug Resistance, Multiple, Bacterial
  • Enterobacter cloacae / classification*
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / genetics*
  • Enterobacter cloacae / isolation & purification
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology*
  • Genes, Bacterial
  • Genes, Essential
  • Genetic Variation*
  • Genotype*
  • Global Health
  • Humans
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Multilocus Sequence Typing
  • Sequence Analysis, DNA

Associated data

  • GENBANK/KM985624
  • GENBANK/KM985625
  • GENBANK/KM985626
  • GENBANK/KM985627
  • GENBANK/KM985628