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Page 1
Effects of menopause on temperature regulation.
Gombert-Labedens M, Vesterdorf K, Fuller A, Maloney SK, Baker FC. Gombert-Labedens M, et al. Temperature (Austin). 2025 Apr 23;12(2):92-132. doi: 10.1080/23328940.2025.2484499. eCollection 2025. Temperature (Austin). 2025. PMID: 40330614 Free PMC article. Review.
Changes in thermoregulation, notably the emergence of hot flashes, occur during the menopause transition in association with reproductive hormonal changes. ...Finally, we highlight gaps in knowledge about menopausal thermoregulation and hot f …
Changes in thermoregulation, notably the emergence of hot flashes, occur during the menopause transition in association …
Fezolinetant in the treatment of vasomotor symptoms associated with menopause.
Depypere H, Lademacher C, Siddiqui E, Fraser GL. Depypere H, et al. Expert Opin Investig Drugs. 2021 Jul;30(7):681-694. doi: 10.1080/13543784.2021.1893305. Epub 2021 Jul 12. Expert Opin Investig Drugs. 2021. PMID: 33724119 Free article. Review.
There is therefore a need for safe, effective non-hormonal therapy for relief of menopausal vasomotor symptoms (VMS).Areas covered: This narrative review summarizes the dataset accrued for fezolinetant, a neurokinin-3 receptor (NK3R) antagonist in clinical development for …
There is therefore a need for safe, effective non-hormonal therapy for relief of menopausal vasomotor symptoms (VMS).Areas covered: T …
Kisspeptin and neurokinin B: roles in reproductive health.
Koysombat K, Tsoutsouki J, Patel AH, Comninos AN, Dhillo WS, Abbara A. Koysombat K, et al. Physiol Rev. 2025 Apr 1;105(2):707-764. doi: 10.1152/physrev.00015.2024. Epub 2025 Jan 15. Physiol Rev. 2025. PMID: 39813600 Free PMC article. Review.
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which coexpress NKB …
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function inclu …
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes.
Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Rance NE, et al. Front Neuroendocrinol. 2013 Aug;34(3):211-27. doi: 10.1016/j.yfrne.2013.07.003. Epub 2013 Jul 17. Front Neuroendocrinol. 2013. PMID: 23872331 Free PMC article. Review.
Based on the marked changes in hypothalamic kisspeptin, neurokinin B and dynorphin (KNDy) neurons in postmenopausal women, we hypothesize that KNDy neurons play a role in the mechanism of flushes. ...These data suggest that arcuate KNDy neuro …
Based on the marked changes in hypothalamic kisspeptin, neurokinin B and dynorphin (KNDy) neurons in postmenopausal women, we …
The role of KNDy neurons in human reproductive health.
Oride A, Kanasaki H. Oride A, et al. Endocr J. 2024 Aug 8;71(8):733-743. doi: 10.1507/endocrj.EJ24-0006. Epub 2024 Jun 12. Endocr J. 2024. PMID: 38866494 Free article. Review.
ARC Kiss1 neurons co-express neurokinin B (NKB) and dynorphin and are thus termed KNDy neurons. Kiss1 neurons in humans are concentrated in the infundibular nucleus (equivalent to the ARC), with few Kiss1 neurons localized to the preoptic area ( …
ARC Kiss1 neurons co-express neurokinin B (NKB) and dynorphin and are thus termed KNDy neurons. Kiss1 neurons in …
Menopause part I: Vasomotor symptoms (I).
Wang PH, Yang ST, Chang WH, Lee WL. Wang PH, et al. Taiwan J Obstet Gynecol. 2025 Mar;64(2):230-238. doi: 10.1016/j.tjog.2025.01.001. Taiwan J Obstet Gynecol. 2025. PMID: 40049806 Free article. Review.
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world. ...Based on this concept, the hypothalamus neural construc …
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathol …
FDA approves Veozah (Fezolinetant) for menopausal symptoms: a new nonhormonal option.
Elendu C, Okahia TW, Blewusi GS, Meduoye OOM, Ogelle EC, Egbo AR, Nwankwo VC, Amaefule KC, Emechebe SL, Mohamed AA, Ogedengbe OS, Aggreh OP, Obi DI, Orji VI, Bakare SO, Adediran FD, Adetoye F, Akande BA, Ogunsola OC, Olanlege AM. Elendu C, et al. Ann Med Surg (Lond). 2025 Jul 30;87(9):5373-5377. doi: 10.1097/MS9.0000000000003670. eCollection 2025 Sep. Ann Med Surg (Lond). 2025. PMID: 40901162 Free PMC article.
Menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats, significantly impact the quality of life for many women. ...Fezolinetant modulates the activity of KNDy neurons in the hypothalamus, which plays a key role in thermoregul …
Menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats, significantly impact the quality of life for …
A New Hope for Woman with Vasomotor Symptoms: Neurokinin B Antagonists.
Meczekalski B, Kostrzak A, Unogu C, Bochynska S, Maciejewska-Jeske M, Bala G, Szeliga A. Meczekalski B, et al. J Clin Med. 2025 Feb 21;14(5):1438. doi: 10.3390/jcm14051438. J Clin Med. 2025. PMID: 40094924 Free PMC article. Review.
KNDy (kisspeptine, neurokinin B, dynorphin) neurons, located in the hypothalamus, play a crucial role in the development of vasomotor symptoms (VSM) in menopausal women. ...The identification of NKB/neurokinin B receptor (NK3R) signaling as a key mechanism in …
KNDy (kisspeptine, neurokinin B, dynorphin) neurons, located in the hypothalamus, play a crucial role in the development of va …
Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause.
Conklin M, Santoro N. Conklin M, et al. Ther Adv Reprod Health. 2023 Jun 22;17:26334941231177611. doi: 10.1177/26334941231177611. eCollection 2023 Jan-Dec. Ther Adv Reprod Health. 2023. PMID: 37388717 Free PMC article. Review.
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women's quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration …
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women's quality of life …
Non-hormonal pharmacological interventions for managing vasomotor symptoms-how can we help: 2024 landscape.
Pertynska-Marczewska M, Pertynski T. Pertynska-Marczewska M, et al. Eur J Obstet Gynecol Reprod Biol. 2024 Nov;302:141-148. doi: 10.1016/j.ejogrb.2024.09.013. Epub 2024 Sep 12. Eur J Obstet Gynecol Reprod Biol. 2024. PMID: 39270577 Review.
The loss of thermoregulatory control coexists with the altered Kisspeptin- Neurokinin B-Dynorphin-expressing (KNDy) neurons of the arcuate nucleus signaling triggered by menopause. OBJECTIVE: Aim of the review was to explore evidence-based non-hormonal pharma …
The loss of thermoregulatory control coexists with the altered Kisspeptin- Neurokinin B-Dynorphin-expressing (KNDy) neurons of …
18 results