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Terminal signal: anti-inflammatory effects of alpha-melanocyte-stimulating hormone related peptides beyond the pharmacophore.
Brzoska T, Böhm M, Lügering A, Loser K, Luger TA. Brzoska T, et al. Adv Exp Med Biol. 2010;681:107-16. doi: 10.1007/978-1-4419-6354-3_8. Adv Exp Med Biol. 2010. PMID: 21222263 Review.
During the last two decades a significant number of investigations has established the fact that alpha-Melanocyte-stimulating hormone (alpha-MSH) is a potent anti-inflammatory mediator. ...These alpha-MSH related tripeptides thus may be u …
During the last two decades a significant number of investigations has established the fact that alpha-Melanocyte-stimulating hormone …
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.
Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Kannengiesser K, et al. Inflamm Bowel Dis. 2008 Mar;14(3):324-31. doi: 10.1002/ibd.20334. Inflamm Bowel Dis. 2008. PMID: 18092346
The anti-inflammatory effects of melanocortin peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) have been described recently in, for example, dextran sodium sulfate (DSS) colitis in mice. The aim of this study was to investigate the the …
The anti-inflammatory effects of melanocortin peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) …
alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.
Luger TA, Brzoska T. Luger TA, et al. Ann Rheum Dis. 2007 Nov;66 Suppl 3(Suppl 3):iii52-5. doi: 10.1136/ard.2007.079780. Ann Rheum Dis. 2007. PMID: 17934097 Free PMC article.
Thus alpha-MSH may modulate inflammatory cell proliferation, activity and migration. The anti-inflammatory effects of alpha-MSH have been confirmed by means of animal models of inflammation such as irritant and allergic contact dermatitis …
Thus alpha-MSH may modulate inflammatory cell proliferation, activity and migration. The anti-inflammatory effec …
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.
Gravina AG, Pellegrino R, Durante T, Palladino G, Imperio G, D'Amico G, Trotta MC, Dallio M, Romeo M, D'Amico M, Federico A. Gravina AG, et al. Cells. 2023 Jul 19;12(14):1889. doi: 10.3390/cells12141889. Cells. 2023. PMID: 37508552 Free PMC article. Review.
These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the latter context, the system has assumed importance in conditions of chronic digestive inflammation, such as inflammatory bowel …
These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the …
Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Rodrigues JM, Ferreira Leal AP, Buccini DF, Franco OL. Rodrigues JM, et al. Drug Discov Today. 2025 Dec;30(12):104535. doi: 10.1016/j.drudis.2025.104535. Epub 2025 Nov 13. Drug Discov Today. 2025. PMID: 41241376 Review.
Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and tissue damage. ...LL-37-Talpha1, lipid transfer protein (LTP), C-L, KR-12], defensins [e.g. human alpha defensin 5 (HD-5), human bet …
Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and …
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.
Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Brzoska T, et al. Endocr Rev. 2008 Aug;29(5):581-602. doi: 10.1210/er.2007-0027. Epub 2008 Jul 8. Endocr Rev. 2008. PMID: 18612139 Review.
Alpha-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence that alpha-MSH has potent protective and antiinflammatory effects. ...One obstacle limiting the use of alpha-MSH i …
Alpha-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence th …