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2000 3
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27 results

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Page 1
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-kappaB pathway.
Sung J, Ju SY, Park S, Jung WK, Je JY, Lee SJ. Sung J, et al. Tissue Cell. 2025 Aug;95:102837. doi: 10.1016/j.tice.2025.102837. Epub 2025 Mar 6. Tissue Cell. 2025. PMID: 40073467
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide …
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation …
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Cheng J, Wu P, Li C, Han Y, Sun M, Dou Y, Chen S, Zhang J. Cheng J, et al. Sci Adv. 2026 Jan 16;12(3):eaea2989. doi: 10.1126/sciadv.aea2989. Epub 2026 Jan 14. Sci Adv. 2026. PMID: 41533788 Free PMC article.
Using three anti-inflammatory peptides (KPV, Ac-QAW, and IRW), we demonstrated that the engineered conjugates exhibit remarkable GI stability, efficient mucus penetration, and ROS-responsive release at inflamed sites. In colitis mice, the KPV-based conjugate …
Using three anti-inflammatory peptides (KPV, Ac-QAW, and IRW), we demonstrated that the engineered conjugates exhibit remarkab …
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. Dalmasso G, et al. Gastroenterology. 2008 Jan;134(1):166-78. doi: 10.1053/j.gastro.2007.10.026. Epub 2007 Oct 17. Gastroenterology. 2008. PMID: 18061177 Free PMC article.
Uptake experiments were performed using cold KPV as a competitor for PepT1 radiolabelled substrate or using [(3)H]KPV to determine kinetic characteristics of KPV uptake. Anti-inflammatory effect of KPV was also investigated in DSS- and TNBS-induced col …
Uptake experiments were performed using cold KPV as a competitor for PepT1 radiolabelled substrate or using [(3)H]KPV to deter …
The neuroimmunomodulatory peptide alpha-MSH.
Ichiyama T, Sato S, Okada K, Catania A, Lipton JM. Ichiyama T, et al. Ann N Y Acad Sci. 2000;917:221-6. doi: 10.1111/j.1749-6632.2000.tb05386.x. Ann N Y Acad Sci. 2000. PMID: 11268347 Review.
Cells transfected with alpha-MSH plasmid vector are resistant to challenge with bacterial lipopolysaccharide. The peptide also act on central melanocortin receptors to modulate inflammation in the periphery. In brief, alpha-MSH and certain of its fragments such as a …
Cells transfected with alpha-MSH plasmid vector are resistant to challenge with bacterial lipopolysaccharide. The peptide also act on …
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Zeng K, Zhu Y, Han Z, Xiong S, Zhao Y, Xiao Z, Xie Y, Jin S, Dong T, Lan L, Liu W, Du Y, Guan C, Yu X, Song X. Zeng K, et al. Cell Death Differ. 2026 Feb;33(2):343-357. doi: 10.1038/s41418-025-01578-5. Epub 2025 Sep 11. Cell Death Differ. 2026. PMID: 40935835
This disruption impairs the selective autophagic degradation of NLRP3, leading to hyperactivation of inflammation and pyroptosis in melanocytes, thereby accelerating vitiligo pathogenesis. Notably, melanocyte-specific knockdown of NLRP3 using lysine-proline-valine (KPV …
This disruption impairs the selective autophagic degradation of NLRP3, leading to hyperactivation of inflammation and pyroptosis in m …
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.
Zeng M, Shao A, Li H, Tang Y, Li Q, Guo Z, Wu C, Cheng Y, Tian H, Zhu WH. Zeng M, et al. ACS Appl Mater Interfaces. 2017 Apr 19;9(15):13029-13036. doi: 10.1021/acsami.7b00936. Epub 2017 Apr 7. ACS Appl Mater Interfaces. 2017. PMID: 28349696
Herein, we report a PepT1 peptide receptor-targeted fluorescent probe, dicyanomethylene-4H-pyran (DCM)-KPV, with the strategy of conjugating the KPV into the DCM chromophore. ...We build the overexpressed PepT1 on the cytomembrane of ulcerative colitis model …
Herein, we report a PepT1 peptide receptor-targeted fluorescent probe, dicyanomethylene-4H-pyran (DCM)-KPV, with the strategy …
Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.
Laroui H, Dalmasso G, Nguyen HT, Yan Y, Sitaraman SV, Merlin D. Laroui H, et al. Gastroenterology. 2010 Mar;138(3):843-53.e1-2. doi: 10.1053/j.gastro.2009.11.003. Epub 2009 Nov 10. Gastroenterology. 2010. PMID: 19909746
METHODS: NPs were synthesized by double-emulsion/solvent evaporation. KPV was loaded into the NPs during the first emulsion of the synthesis process. To target KPV to the colon, loaded NPs (NP-KPV) were encapsulated into a polysaccharide gel containing 2 poly …
METHODS: NPs were synthesized by double-emulsion/solvent evaporation. KPV was loaded into the NPs during the first emulsion of the sy …
KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Zhang L, Li D, Aierken Y, Zhang J, Liu Z, Lin Z, Jiang L, Li Q, Wu Y, Liu Y. Zhang L, et al. Adv Healthc Mater. 2024 Dec;13(32):e2402320. doi: 10.1002/adhm.202402320. Epub 2024 Sep 10. Adv Healthc Mater. 2024. PMID: 39252648
Thus, developing a simple, efficient, and safe nanodrug to simultaneously regulate inflammation and autophagy may be a promising strategy for treating VC. Herein, an anti-inflammatory peptide (lysine-proline-valine peptides, KPV) and the autophagy acti …
Thus, developing a simple, efficient, and safe nanodrug to simultaneously regulate inflammation and autophagy may be a promising stra …
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.
Getting SJ, Schiöth HB, Perretti M. Getting SJ, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):631-7. doi: 10.1124/jpet.103.051623. Epub 2003 May 15. J Pharmacol Exp Ther. 2003. PMID: 12750433
The anti-inflammatory properties of KPV were also evident in IL-1beta-induced peritonitis inflammation and in mice with a nonfunctional MC1-R (recessive yellow e/e mice). In conclusion, these data highlight that the C-terminal MSH peptide KPV exhibits …
The anti-inflammatory properties of KPV were also evident in IL-1beta-induced peritonitis inflammation and in mice with a nonf …
Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.
Land SC. Land SC. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73. Epub 2012 Jun 23. Int J Physiol Pathophysiol Pharmacol. 2012. PMID: 22837805 Free PMC article.
This study investigates the mechanism by which the alpha-melanocyte stimulating hormone-derived tripeptide, KPV, and the agonist of the dominant melanocortin receptor in airway epithelium (MC3R), gamma-melanocyte stimulating hormone (gamma-MSH), suppress inflammation …
This study investigates the mechanism by which the alpha-melanocyte stimulating hormone-derived tripeptide, KPV, and the agonist of t …
27 results