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127 results
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Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation.
Powell SN, Kachnic LA. Powell SN, et al. Among authors: kachnic la. Oncogene. 2003 Sep 1;22(37):5784-91. doi: 10.1038/sj.onc.1206678. Oncogene. 2003. PMID: 12947386 Review.
Inactivation of p53 results in high rates of homologous recombination.
Mekeel KL, Tang W, Kachnic LA, Luo CM, DeFrank JS, Powell SN. Mekeel KL, et al. Among authors: kachnic la. Oncogene. 1997 Apr 17;14(15):1847-57. doi: 10.1038/sj.onc.1201143. Oncogene. 1997. PMID: 9150391
Radiation therapy in the management of rectal cancer.
Kachnic LA, Willett CG. Kachnic LA, et al. Curr Opin Oncol. 2001 Jul;13(4):300-6. doi: 10.1097/00001622-200107000-00014. Curr Opin Oncol. 2001. PMID: 11429489 Review.
Risk of lymphedema after regional nodal irradiation with breast conservation therapy.
Coen JJ, Taghian AG, Kachnic LA, Assaad SI, Powell SN. Coen JJ, et al. Among authors: kachnic la. Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1209-15. doi: 10.1016/s0360-3016(02)04273-6. Int J Radiat Oncol Biol Phys. 2003. PMID: 12654429 Review.
Advances in combined radiation therapy for the management of rectal cancer.
Kachnic LA, Shih HA, Willett CG. Kachnic LA, et al. Expert Rev Anticancer Ther. 2003 Aug;3(4):471-83. doi: 10.1586/14737140.3.4.471. Expert Rev Anticancer Ther. 2003. PMID: 12934659 Review.
The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancer.
Yock TI, Taghian AG, Kachnic LA, Coen JJ, Assaad SI, Powell SN. Yock TI, et al. Among authors: kachnic la. Breast Cancer Res Treat. 2004 Mar;84(2):161-71. doi: 10.1023/B:BREA.0000018414.36274.72. Breast Cancer Res Treat. 2004. PMID: 14999146
DNA damage induces p53-dependent BRCA1 nuclear export.
Feng Z, Kachnic L, Zhang J, Powell SN, Xia F. Feng Z, et al. J Biol Chem. 2004 Jul 2;279(27):28574-84. doi: 10.1074/jbc.M404137200. Epub 2004 Apr 15. J Biol Chem. 2004. PMID: 15087457
BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II.
Treszezamsky AD, Kachnic LA, Feng Z, Zhang J, Tokadjian C, Powell SN. Treszezamsky AD, et al. Among authors: kachnic la. Cancer Res. 2007 Aug 1;67(15):7078-81. doi: 10.1158/0008-5472.CAN-07-0601. Cancer Res. 2007. PMID: 17671173
Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.
Evans JW, Chernikova SB, Kachnic LA, Banath JP, Sordet O, Delahoussaye YM, Treszezamsky A, Chon BH, Feng Z, Gu Y, Wilson WR, Pommier Y, Olive PL, Powell SN, Brown JM. Evans JW, et al. Among authors: kachnic la. Cancer Res. 2008 Jan 1;68(1):257-65. doi: 10.1158/0008-5472.CAN-06-4497. Cancer Res. 2008. PMID: 18172318
Therapeutic exploitation of tumor cell defects in homologous recombination.
Powell SN, Kachnic LA. Powell SN, et al. Among authors: kachnic la. Anticancer Agents Med Chem. 2008 May;8(4):448-60. doi: 10.2174/187152008784220267. Anticancer Agents Med Chem. 2008. PMID: 18473729 Review.
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