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219 results
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK. Shi DD, et al. Among authors: kaelin wg jr. Cancer Cell. 2022 Sep 12;40(9):939-956.e16. doi: 10.1016/j.ccell.2022.07.011. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985343 Free PMC article.
David M. Livingston (1941-2021).
Kaelin WG Jr. Kaelin WG Jr. Cell. 2021 Dec 9;184(25):6007-6009. doi: 10.1016/j.cell.2021.11.006. Cell. 2021. PMID: 34890547 No abstract available.
Belzutifan, a Potent HIF2α Inhibitor, in the Pacak-Zhuang Syndrome.
Kamihara J, Hamilton KV, Pollard JA, Clinton CM, Madden JA, Lin J, Imamovic A, Wall CB, Wassner AJ, Weil BR, Heeney MM, Vargas SO, Kaelin WG Jr, Janeway KA, Perini RF, Zojwalla NJ, Voss SD, DuBois SG. Kamihara J, et al. Among authors: kaelin wg jr. N Engl J Med. 2021 Nov 25;385(22):2059-2065. doi: 10.1056/NEJMoa2110051. N Engl J Med. 2021. PMID: 34818480
Targeting oncoproteins with a positive selection assay for protein degraders.
Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr. Koduri V, et al. Among authors: kaelin wg jr. Sci Adv. 2021 Feb 5;7(6):eabd6263. doi: 10.1126/sciadv.abd6263. Print 2021 Feb. Sci Adv. 2021. PMID: 33547076 Free PMC article.
2-Oxoglutarate-dependent dioxygenases in cancer.
Losman JA, Koivunen P, Kaelin WG Jr. Losman JA, et al. Among authors: kaelin wg jr. Nat Rev Cancer. 2020 Dec;20(12):710-726. doi: 10.1038/s41568-020-00303-3. Epub 2020 Oct 21. Nat Rev Cancer. 2020. PMID: 33087883 Review.
Targeting the HIF2-VEGF axis in renal cell carcinoma.
Choueiri TK, Kaelin WG Jr. Choueiri TK, et al. Among authors: kaelin wg jr. Nat Med. 2020 Oct;26(10):1519-1530. doi: 10.1038/s41591-020-1093-z. Epub 2020 Oct 5. Nat Med. 2020. PMID: 33020645 Review.
219 results