Kahle KT - Search Results

1

GABA_A receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl^--sensitive WNK1 kinase.

Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S. Heubl M, et al. Among authors: kahle kt. Nat Commun. 2017 Nov 24;8(1):1776. doi: 10.1038/s41467-017-01749-0. Nat Commun. 2017. PMID: 29176664 Free PMC article.

2

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2.

Kahle KT, Deeb TZ, Puskarjov M, Silayeva L, Liang B, Kaila K, Moss SJ. Kahle KT, et al. Trends Neurosci. 2013 Dec;36(12):726-737. doi: 10.1016/j.tins.2013.08.006. Epub 2013 Oct 15. Trends Neurosci. 2013. PMID: 24139641 Free PMC article. Review.

3

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. de Los Heros P, et al. Among authors: kahle kt. Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478. Biochem J. 2014. PMID: 24393035 Free PMC article.

4

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. Alessi DR, et al. Among authors: kahle kt. Sci Signal. 2014 Jul 15;7(334):re3. doi: 10.1126/scisignal.2005365. Sci Signal. 2014. PMID: 25028718 Review.

5

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. Friedel P, et al. Among authors: kahle kt. Sci Signal. 2015 Jun 30;8(383):ra65. doi: 10.1126/scisignal.aaa0354. Sci Signal. 2015. PMID: 26126716

6

Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.

Kahle KT, Delpire E. Kahle KT, et al. J Neurophysiol. 2016 Jan 1;115(1):8-18. doi: 10.1152/jn.00865.2015. Epub 2015 Oct 28. J Neurophysiol. 2016. PMID: 26510764 Free PMC article. Review.

7

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.

Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Kahle KT, et al. Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163. Sci Signal. 2016. PMID: 27025876 Free PMC article.

8

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.

Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Kahle KT, et al. Sci Signal. 2016 Aug 2;9(439):ra77. doi: 10.1126/scisignal.aae0546. Sci Signal. 2016. PMID: 27485015 Free PMC article.

9

Functional kinomics establishes a critical node of volume-sensitive cation-Cl^- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Zhang J, et al. Among authors: kahle kt. Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986. Sci Rep. 2016. PMID: 27782176 Free PMC article.

10

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.

Zhang J, Deng X, Kahle KT. Zhang J, et al. Among authors: kahle kt. Sci Signal. 2016 Oct 18;9(450):e3. doi: 10.1126/scisignal.aaj2227. Sci Signal. 2016. PMID: 27811182 Review.

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