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Glucose-stimulated genes and prospects of gene therapy for type I diabetes.
Mitanchez D, Doiron B, Chen R, Kahn A. Mitanchez D, et al. Among authors: kahn a. Endocr Rev. 1997 Aug;18(4):520-40. doi: 10.1210/edrv.18.4.0307. Endocr Rev. 1997. PMID: 9267763 Review. No abstract available.
[From genomics to treatment].
Kahn A. Kahn A. Presse Med. 2004 Jun 15;33 Spec No:Sp53-5. Presse Med. 2004. PMID: 15360148 French. No abstract available.
Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout.
Bardoux P, Zhang P, Flamez D, Perilhou A, Lavin TA, Tanti JF, Hellemans K, Gomas E, Godard C, Andreelli F, Buccheri MA, Kahn A, Le Marchand-Brustel Y, Burcelin R, Schuit F, Vasseur-Cognet M. Bardoux P, et al. Among authors: kahn a. Diabetes. 2005 May;54(5):1357-63. doi: 10.2337/diabetes.54.5.1357. Diabetes. 2005. PMID: 15855320
Moreover, these heterozygous mice presented a mild increase in fasting and random-fed circulating insulin levels. In accordance, islets isolated from these animals exhibited higher insulin secretion in low glucose conditions and markedly decreased glucose-stimulated insuli …
Moreover, these heterozygous mice presented a mild increase in fasting and random-fed circulating insulin levels. In accordance, isle …
A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver.
Tannour-Louet M, Porteu A, Vaulont S, Kahn A, Vasseur-Cognet M. Tannour-Louet M, et al. Among authors: kahn a. Hepatology. 2002 May;35(5):1072-81. doi: 10.1053/jhep.2002.33164. Hepatology. 2002. PMID: 11981757
The spatiotemporal control of somatic mutagenesis in mice is considered a promising step to determine the function of a given gene product in a defined population of cells at any given time during animal life and also to generate better mouse models of human …
The spatiotemporal control of somatic mutagenesis in mice is considered a promising step to determine the function of a given …
Identification of the IFITM family as a new molecular marker in human colorectal tumors.
Andreu P, Colnot S, Godard C, Laurent-Puig P, Lamarque D, Kahn A, Perret C, Romagnolo B. Andreu P, et al. Among authors: kahn a. Cancer Res. 2006 Feb 15;66(4):1949-55. doi: 10.1158/0008-5472.CAN-05-2731. Cancer Res. 2006. PMID: 16488993
Using a conditional mouse model of Apc inactivation and a human colon carcinoma cell line, we showed that IFITM gene expression is rapidly induced after activation of the beta-catenin signaling. Using a large-scale analysis of human tumors, we showed that IFI …
Using a conditional mouse model of Apc inactivation and a human colon carcinoma cell line, we showed that IFITM gene expressio …
Hepcidin, a new iron regulatory peptide.
Nicolas G, Viatte L, Bennoun M, Beaumont C, Kahn A, Vaulont S. Nicolas G, et al. Among authors: kahn a. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):327-35. doi: 10.1006/bcmd.2002.0573. Blood Cells Mol Dis. 2002. PMID: 12547223
Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. ...
Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role i …
Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene.
Skala-Rubinson H, Vinh J, Labas V, Kahn A, Phan DT. Skala-Rubinson H, et al. Among authors: kahn a. J Biol Chem. 2002 Dec 6;277(49):47190-6. doi: 10.1074/jbc.M209349200. Epub 2002 Oct 4. J Biol Chem. 2002. PMID: 12370174
., Porteu, A., Thomas, M., Szajnert, M. F., Okazawa, H., Kahn, A., and Phan-Dinh-Tuy, F. (1998) J. Biol. Chem. 273, 31806-31814), we have identified two novel DNA elements critical for an interaction with a brain-specific, high affinity DNA-binding pro …
., Porteu, A., Thomas, M., Szajnert, M. F., Okazawa, H., Kahn, A., and Phan-Dinh-Tuy, F. (1998) J. Biol. Chem. 273, 318 …
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism.
Cadoret A, Ovejero C, Terris B, Souil E, Lévy L, Lamers WH, Kitajewski J, Kahn A, Perret C. Cadoret A, et al. Among authors: kahn a. Oncogene. 2002 Nov 28;21(54):8293-301. doi: 10.1038/sj.onc.1206118. Oncogene. 2002. PMID: 12447692
By contrast no up-regulation of these three genes was observed in the liver in which hepatocyte proliferation was induced by a signal-independent of beta-catenin. ...Together, our results indicate that GS is a target of the Wnt/beta-catenin pathway in the liver. Bec …
By contrast no up-regulation of these three genes was observed in the liver in which hepatocyte proliferation was induced by a signal …
[Liver repopulation strategies].
Gilgenkrantz H, Guidotti JE, Mitchell C, Mallet VO, Kahn A. Gilgenkrantz H, et al. Among authors: kahn a. Bull Acad Natl Med. 2005 Apr;189(4):625-33. Bull Acad Natl Med. 2005. PMID: 16245681 Review. French.
We conferred a survival advantage on transplanted hepatocytes and showed that they were able to repopulate almost the entire mouse liver after repeated injury. ...
We conferred a survival advantage on transplanted hepatocytes and showed that they were able to repopulate almost the entire mouse li …
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C, Colnot S. Benhamouche S, et al. Among authors: kahn a. Dev Cell. 2006 Jun;10(6):759-70. doi: 10.1016/j.devcel.2006.03.015. Dev Cell. 2006. PMID: 16740478
The molecular mechanisms by which liver genes are differentially expressed along a portocentral axis, allowing for metabolic zonation, are poorly understood. ...We then analyzed the immediate consequences of either a liver-inducible Apc disruption or a blocka …
The molecular mechanisms by which liver genes are differentially expressed along a portocentral axis, allowing for metabolic zonation …
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