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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Mueller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert M, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Ren AA, et al. Among authors: kahn ml. Nature. 2021 Apr 28. doi: 10.1038/s41586-021-03562-8. Online ahead of print. Nature. 2021. PMID: 33910229
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Hong CC, et al. Among authors: kahn ml. J Exp Med. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140. J Exp Med. 2020. PMID: 32648916 Free PMC article.
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.
Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA. Polster SP, et al. Among authors: kahn ml. Nat Commun. 2020 May 27;11(1):2659. doi: 10.1038/s41467-020-16436-w. Nat Commun. 2020. PMID: 32461638 Free PMC article.
The Ouzo effect: A tool to elaborate high-payload nanocapsules.
Goubault C, Sciortino F, Mongin O, Jarry U, Bostoën M, Jakobczyk H, Burel A, Dutertre S, Troadec MB, Kahn ML, Chevance S, Gauffre F. Goubault C, et al. Among authors: kahn ml. J Control Release. 2020 Aug 10;324:430-439. doi: 10.1016/j.jconrel.2020.05.023. Epub 2020 May 18. J Control Release. 2020. PMID: 32439361 Free article.
Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1 K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth.
Szoták-Ajtay K, Szõke D, Kovács G, Andréka J, Brenner GB, Giricz Z, Penninger J, Kahn ML, Jakus Z. Szoták-Ajtay K, et al. Among authors: kahn ml. Front Bioeng Biotechnol. 2020 Mar 6;8:136. doi: 10.3389/fbioe.2020.00136. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32211389 Free PMC article.
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