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Visualizing the effect of hypoxia on fluorescence kinetics in living HeLa cells using the fluorescent ubiquitination-based cell cycle indicator (Fucci).
Kaida A, Miura M. Kaida A, et al. Exp Cell Res. 2012 Feb 1;318(3):288-97. doi: 10.1016/j.yexcr.2011.10.016. Epub 2011 Nov 3. Exp Cell Res. 2012. PMID: 22079518
The abrogation of fluorescence resulted from a combination of ubiquitination-dependent degradation of pre-existing functional proteins during specific cell cycle phases, and the expression of newly synthesized non-fluorescent proteins containing non-oxidized chromophore du …
The abrogation of fluorescence resulted from a combination of ubiquitination-dependent degradation of pre-existing functional protein …
DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.
Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M. Jiaranuchart S, et al. Among authors: kaida a. Arch Oral Biol. 2018 Jun;90:1-8. doi: 10.1016/j.archoralbio.2018.02.016. Epub 2018 Mar 6. Arch Oral Biol. 2018. PMID: 29522917
Pedigree analysis of Fucci fluorescence revealed that the HSC3-Fucci cells exhibited a significantly longer green phase (normally indicating S/G2/M phases, but here reflective of G2 arrest) when irradiated in the red phase (G1 phase) than HSC4-Fucci cells irradiated in eit …
Pedigree analysis of Fucci fluorescence revealed that the HSC3-Fucci cells exhibited a significantly longer green phase (normally ind …
Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells.
Manila NG, Kaida A, Nakahama KI, Miura M. Manila NG, et al. Among authors: kaida a. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2977-2983. doi: 10.1016/j.bbrc.2018.08.080. Epub 2018 Aug 16. Biochem Biophys Res Commun. 2018. PMID: 30119887
Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids.
Onozato Y, Kaida A, Harada H, Miura M. Onozato Y, et al. Among authors: kaida a. Cancer Sci. 2017 Apr;108(4):704-712. doi: 10.1111/cas.13178. Epub 2017 Apr 16. Cancer Sci. 2017. PMID: 28135769 Free PMC article.
In this study, we succeeded in separately isolating different cell types using a fluorescent ubiquitination-based cell cycle indicator (Fucci) and determining their radiosensitivities. ...Interestingly, the central region of the spheroid entered a dormant stage appr …
In this study, we succeeded in separately isolating different cell types using a fluorescent ubiquitination-based cell cycle indicato …
Temporo-spatial cell-cycle kinetics in HeLa cells irradiated by Ir-192 high dose-rate remote afterloading system (HDR-RALS).
Asahina T, Kaida A, Goto T, Yoshimura R, Sasai K, Miura M. Asahina T, et al. Among authors: kaida a. Radiat Oncol. 2016 Jul 29;11:99. doi: 10.1186/s13014-016-0669-8. Radiat Oncol. 2016. PMID: 27473168 Free PMC article.
Under this condition, tumor tissues receive remarkably different absorption doses, with a steep gradient, depending on distance from the radiation source. ...A 6 French (Fr) catheter was used as an applicator. A radiation dose of 6 Gy was prescribed at hypoth …
Under this condition, tumor tissues receive remarkably different absorption doses, with a steep gradient, depending on distance from …
KPU-300, a Novel Benzophenone-Diketopiperazine-Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase.
Okuyama K, Kaida A, Hayashi Y, Hayashi Y, Harada K, Miura M. Okuyama K, et al. Among authors: kaida a. PLoS One. 2015 Dec 30;10(12):e0145995. doi: 10.1371/journal.pone.0145995. eCollection 2015. PLoS One. 2015. PMID: 26716455 Free PMC article.
When such drug-treated cells were irradiated in monolayer, a remarkable radiosensitization was observed. To determine whether this radiosensitization was truly due to the synchronization in M phase, we compared the radiosensitivity of cells synchronized by KPU-300 treatmen …
When such drug-treated cells were irradiated in monolayer, a remarkable radiosensitization was observed. To determine whether this ra …
Visualizing cell-cycle kinetics after hypoxia/reoxygenation in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci).
Goto T, Kaida A, Miura M. Goto T, et al. Among authors: kaida a. Exp Cell Res. 2015 Dec 10;339(2):389-96. doi: 10.1016/j.yexcr.2015.10.019. Epub 2015 Oct 20. Exp Cell Res. 2015. PMID: 26500111
Unusual prolongation of radiation-induced G2 arrest in tumor xenografts derived from HeLa cells.
Kaida A, Miura M. Kaida A, et al. Cancer Sci. 2015 Oct;106(10):1370-6. doi: 10.1111/cas.12748. Epub 2015 Sep 4. Cancer Sci. 2015. PMID: 26195156 Free PMC article.
Cells isolated from tumors 5 days after irradiation exhibited a higher surviving fraction than those isolated immediately or one day after irradiation. ...Our findings imply that prolonged G2 arrest occurring in tumor microenvironments following irradiation may function as …
Cells isolated from tumors 5 days after irradiation exhibited a higher surviving fraction than those isolated immediately or one day …
Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell-Based Kinetics in an Asynchronous Cell Population.
Tsuchida E, Kaida A, Pratama E, Ikeda MA, Suzuki K, Harada K, Miura M. Tsuchida E, et al. Among authors: kaida a. PLoS One. 2015 Jun 18;10(6):e0128090. doi: 10.1371/journal.pone.0128090. eCollection 2015. PLoS One. 2015. PMID: 26086724 Free PMC article.
We next established a method for classifying the green phase into early S, mid S, late S, and G2 phases at the time of irradiation, and then attempted to estimate the duration of G2 arrest based on certain assumptions. ...
We next established a method for classifying the green phase into early S, mid S, late S, and G2 phases at the time of irradiation, a …
Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells.
Nahar K, Goto T, Kaida A, Deguchi S, Miura M. Nahar K, et al. Among authors: kaida a. J Radiat Res. 2014 Sep;55(5):1021-7. doi: 10.1093/jrr/rru038. Epub 2014 Jun 3. J Radiat Res. 2014. PMID: 24894074 Free PMC article.
Chk1 inhibitor acts as a potent radiosensitizer in p53-deficient tumor cells by abrogating the G2/M checkpoint. However, the effects of Chk1 inhibitor on the duration of G2 arrest have not been precisely analyzed. To address this issue, we utilized a cell-cycle visu …
Chk1 inhibitor acts as a potent radiosensitizer in p53-deficient tumor cells by abrogating the G2/M checkpoint. However, the effects …
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