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Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
Vullo D, Innocenti A, Nishimori I, Scozzafava A, Kaila K, Supuran CT. Vullo D, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4107-12. doi: 10.1016/j.bmcl.2007.05.052. Epub 2007 May 21. Bioorg Med Chem Lett. 2007. PMID: 17540561
An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by L-/D-His, dopamine and serotonin (K(A)s of …
An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amin …
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT. Vullo D, et al. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. doi: 10.1016/j.bmcl.2004.12.052. Bioorg Med Chem Lett. 2005. PMID: 15686895
Inhibition data for the the other physiologically relevant cytosolic isoforms hCA I, hCA II and mCA XIII are also provided for comparison. hCA VII shows a high catalytic activity for the CO(2) hydration reaction, with a k(cat) of 9.5 x 10(5)s(-1) and k(cat)/K
Inhibition data for the the other physiologically relevant cytosolic isoforms hCA I, hCA II and mCA XIII are also provided for comparison. h …
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Vullo D, Ruusuvuori E, Kaila K, Scozzafava A, Supuran CT. Vullo D, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. doi: 10.1016/j.bmcl.2006.03.078. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621537
Cyanate, cyanide, and hydrogensulfite were weak hCA VII inhibitors (K(I)s in the range of 7.3-15.2 mM). Cl- and HCO3- showed good inhibitory activity against hCA VII (K(I)s of 0.16-1.84 mM), suggesting that this enzyme is not involved in metabolons with anion exchan …
Cyanate, cyanide, and hydrogensulfite were weak hCA VII inhibitors (K(I)s in the range of 7.3-15.2 mM). Cl- and HCO3- showed good inh …
Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.
Asiedu MN, Mejia GL, Hübner CA, Kaila K, Price TJ. Asiedu MN, et al. J Pain. 2014 Apr;15(4):395-406. doi: 10.1016/j.jpain.2014.01.001. Epub 2014 Jan 9. J Pain. 2014. PMID: 24412803 Free PMC article.
Peripheral nerve injury (PNI) negatively influences spinal gamma-aminobutyric acid (GABA)ergic networks via a reduction in the neuron-specific potassium-chloride (K(+)-Cl(-)) cotransporter (KCC2). ...
Peripheral nerve injury (PNI) negatively influences spinal gamma-aminobutyric acid (GABA)ergic networks via a reduction in the neuron-specif …
Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells.
Ruusuvuori E, Li H, Huttu K, Palva JM, Smirnov S, Rivera C, Kaila K, Voipio J. Ruusuvuori E, et al. J Neurosci. 2004 Mar 17;24(11):2699-707. doi: 10.1523/JNEUROSCI.5176-03.2004. J Neurosci. 2004. PMID: 15028762 Free PMC article.
Using microfluorescence measurements of intraneuronal pH, in situ hybridization, as well as intracellular, extracellular, and K+-sensitive microelectrode recordings, we show now that the capability for synchronous gamma-frequency (20-80 Hz) firing in response to high-frequ …
Using microfluorescence measurements of intraneuronal pH, in situ hybridization, as well as intracellular, extracellular, and K+-sens …
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.
Rivera C, Voipio J, Kaila K. Rivera C, et al. J Physiol. 2005 Jan 1;562(Pt 1):27-36. doi: 10.1113/jphysiol.2004.077495. Epub 2004 Nov 4. J Physiol. 2005. PMID: 15528236 Free PMC article. Review.
During development the efficacy and also the qualitative nature (depolarization/excitation versus hyperpolarization/inhibition) of GABAergic transmission is influenced by the neuronal expression of two key molecules: the chloride-extruding K(+)-Cl(-) cotransporter KCC2, an …
During development the efficacy and also the qualitative nature (depolarization/excitation versus hyperpolarization/inhibition) of GABAergic …
Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
Ruusuvuori E, Huebner AK, Kirilkin I, Yukin AY, Blaesse P, Helmy M, Kang HJ, El Muayed M, Hennings JC, Voipio J, Šestan N, Hübner CA, Kaila K. Ruusuvuori E, et al. EMBO J. 2013 Aug 14;32(16):2275-86. doi: 10.1038/emboj.2013.160. Epub 2013 Jul 23. EMBO J. 2013. PMID: 23881097 Free PMC article.
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy.
Brandt C, Seja P, Töllner K, Römermann K, Hampel P, Kalesse M, Kipper A, Feit PW, Lykke K, Toft-Bertelsen TL, Paavilainen P, Spoljaric I, Puskarjov M, MacAulay N, Kaila K, Löscher W. Brandt C, et al. Among authors: kaila k. Neuropharmacology. 2018 Dec;143:186-204. doi: 10.1016/j.neuropharm.2018.09.025. Epub 2018 Sep 21. Neuropharmacology. 2018. PMID: 30248303
Forebrain-independent generation of hyperthermic convulsions in infant rats.
Pospelov AS, Yukin AY, Blumberg MS, Puskarjov M, Kaila K. Pospelov AS, et al. Epilepsia. 2016 Jan;57(1):e1-6. doi: 10.1111/epi.13230. Epub 2015 Nov 7. Epilepsia. 2016. PMID: 26547277 Free PMC article.
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