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Integrative systems biology approaches to identify and prioritize disease and drug candidate genes.
Kaimal V, Sardana D, Bardes EE, Gudivada RC, Chen J, Jegga AG. Kaimal V, et al. Methods Mol Biol. 2011;700:241-59. doi: 10.1007/978-1-61737-954-3_16. Methods Mol Biol. 2011. PMID: 21204038
Dissecting microregulation of a master regulatory network.
Sinha AU, Kaimal V, Chen J, Jegga AG. Sinha AU, et al. Among authors: kaimal v. BMC Genomics. 2008 Feb 23;9:88. doi: 10.1186/1471-2164-9-88. BMC Genomics. 2008. PMID: 18294391 Free PMC article.
Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.
Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA. Bessho K, et al. Among authors: kaimal v. BMC Syst Biol. 2013 Oct 20;7:104. doi: 10.1186/1752-0509-7-104. BMC Syst Biol. 2013. PMID: 24138927 Free PMC article.
Atlas of gene expression in the developing kidney at microanatomic resolution.
Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS. Brunskill EW, et al. Among authors: kaimal v. Dev Cell. 2008 Nov;15(5):781-91. doi: 10.1016/j.devcel.2008.09.007. Dev Cell. 2008. PMID: 19000842 Free PMC article.
ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems.
Kaimal V, Bardes EE, Tabar SC, Jegga AG, Aronow BJ. Kaimal V, et al. Nucleic Acids Res. 2010 Jul;38(Web Server issue):W96-102. doi: 10.1093/nar/gkq418. Epub 2010 May 19. Nucleic Acids Res. 2010. PMID: 20484371 Free PMC article.
GenomeTrafac: a whole genome resource for the detection of transcription factor binding site clusters associated with conventional and microRNA encoding genes conserved between mouse and human gene orthologs.
Jegga AG, Chen J, Gowrisankar S, Deshmukh MA, Gudivada R, Kong S, Kaimal V, Aronow BJ. Jegga AG, et al. Among authors: kaimal v. Nucleic Acids Res. 2007 Jan;35(Database issue):D116-21. doi: 10.1093/nar/gkl1011. Epub 2006 Dec 18. Nucleic Acids Res. 2007. PMID: 17178752 Free PMC article.
Staging of biliary atresia at diagnosis by molecular profiling of the liver.
Moyer K, Kaimal V, Pacheco C, Mourya R, Xu H, Shivakumar P, Chakraborty R, Rao M, Magee JC, Bove K, Aronow BJ, Jegga AG, Bezerra JA. Moyer K, et al. Among authors: kaimal v. Genome Med. 2010 May 13;2(5):33. doi: 10.1186/gm154. Genome Med. 2010. PMID: 20465800 Free PMC article.
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways.
Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS. Chau BN, et al. Among authors: kaimal v. Sci Transl Med. 2012 Feb 15;4(121):121ra18. doi: 10.1126/scitranslmed.3003205. Sci Transl Med. 2012. PMID: 22344686 Free PMC article.
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS. Gomez IG, et al. Among authors: kaimal v. J Clin Invest. 2015 Jan;125(1):141-56. doi: 10.1172/JCI75852. Epub 2014 Nov 21. J Clin Invest. 2015. PMID: 25415439 Free PMC article.
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism.
Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V. Hajarnis S, et al. Among authors: kaimal v. Nat Commun. 2017 Feb 16;8:14395. doi: 10.1038/ncomms14395. Nat Commun. 2017. PMID: 28205547 Free PMC article.
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